Results 11 to 20 of about 27,803 (242)
New antagonist agents of neuropeptide y receptors [PDF]
Química Nova, 2000 In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana +8 more
doaj +6 more sources
Neuropeptide Y receptors: How to get subtype selectivity [PDF]
Frontiers in Endocrinology, 2013 The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia +2 more
doaj +4 more sources
Evolution of neuropeptide Y/RFamide-like receptors in nematodes
HeliyonThe Neuropeptide Y/RFamide-like receptors belong to the Rhodopsin-like G protein-coupled receptors G protein-coupled receptors (GPCRs) and are involved in functions such as locomotion, feeding and reproduction.
Franziska Reinhardt +3 more
doaj +4 more sources
Neuropeptide Y receptor in the rat brain [PDF]
European Journal of Biochemistry, 1984 The specific binding of the chloramine-T iodinated neuropeptide Y (125I-NPY) to membranes from rat cerebral cortex was investigated using equilibrium binding and kinetic methods. The equilibrium binding of 125I-NPY at 37 degrees C was characterized by a Kd value of 0.38 nM. The receptor densities in the cerebral cortex, hypothalamus and cerebellum were
Viktor Mutt +3 more
openaire +3 more sources
Characterization of vascular neuropeptide Y receptors [PDF]
British Journal of Pharmacology, 1992 In the present study we compared neuropeptide Y (NPY) and NPY‐related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set‐ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full‐length NPY (1–36) or [Pro34]‐NPY, and Y2 receptors recognizing also N ...
Rolf Håkanson +5 more
openaire +3 more sources
Ligands of the neuropeptide Y Y2 receptor [PDF]
Bioorganic & Medicinal Chemistry Letters, 2014 AbstractReview: 64 refs.
Gopi Kumar Mittapalli, Edward Roberts
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Synthesis of receptor antagonists of neuropeptide Y. [PDF]
Proceedings of the National Academy of Sciences, 1992 We report the synthesis of receptor antagonists of neuropeptide Y (NPY) by a strategy based on synthesis of mixtures of analogs and the subsequent isolation and identification of receptor antagonists from these mixtures. After screening a series of mixtures of NPY analogs by using an NPY antagonist assay, two potent receptor antagonists, designated PYX-
Meikyo Shimizu +2 more
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NPY1R (neuropeptide Y receptor Y1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NPY1R (neuropeptide Y receptor Y1), with data on DNA, on the protein encoded, and where the gene is implicated.
M. Ruscica +3 more
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Y1 and Y2 receptors for neuropeptide Y [PDF]
FEBS Letters, 1989 By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Thue W. Schwartz +2 more
openaire +3 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source