Results 261 to 270 of about 40,251 (303)

Neuropeptide Y receptor antagonists in obesity

Expert Opinion on Investigational Drugs, 1997
Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
D R, Gehlert, P A, Hipskind
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Neuropeptide Y receptors

2002
Abstract Neuropeptide Y (NPY) was isolated from porcine brain almost two decades ago (Tatemoto and Mutt 1980). This 36 amino acid residues shares high sequence homology and structural identity with two other peptides, namely peptide YY (PYY) and pancreatic polypeptide (PP) (Tatemoto et al . 1982).
Yvan Dumont, John Paul Redrobe, Rémi Quirion   +2 more
openaire   +1 more source

Intracellular Trafficking of Neuropeptide Y Receptors

2015
The multireceptor multiligand system of neuropeptide Y receptors and their ligands is involved in the regulation of a multitude of physiological and pathophysiological processes. Specific expression patterns, ligand-binding modes, and signaling properties contribute to the complex network regulating distinct cellular responses.
Karin, Mörl, Annette G, Beck-Sickinger
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Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y

International Endodontic Journal, 2010
Killough SA, Lundy FT, Irwin CR. Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y. International Endodontic Journal, 43, 835–842, 2010.AbstractAim  To investigate whether dental pulp fibroblasts express neuropeptide Y (NPY) and NPY‐Y1 in vitro and to determine the effects of the cytokines including interlukin‐1β (IL‐1β)
Killough, S. A., Lundy, F. T., Irwin, C. R.   +2 more
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Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues

Peptides, 2002
mRNA encoding the human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors.
Rolf, Uddman, Sebastian, Möller, Torun, Nilsson, Susanne, Nyström, Jonas, Ekstrand, Lars, Edvinsson   +5 more
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Neuropeptide y receptor in bovine hippocampus is a Y2 receptor

Life Sciences, 1992
[125I]NPY bound to a single class of saturable binding sites on bovine hippocampus membranes with a KD of 0.1 mM and Bmax of 165 fmol/mg of protein. The rank order of potency of NPY fragments and other structurally related peptides to inhibit [125I]NPY binding was: PYY greater than or equal to NPY much greater than BPP greater than or equal to APP and ...
W, Li, R G, MacDonald, T D, Hexum
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Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists

Bioorganic & Medicinal Chemistry Letters, 2002
Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y(1) binding in a high throughput (125)I-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y(1) receptor antagonist.
Graham S, Poindexter, Marc A, Bruce, Karen L, LeBoulluec, Ivo, Monkovic, Scott W, Martin, Eric M, Parker, Larry G, Iben, Rachel T, McGovern, Astrid A, Ortiz, Jennifer A, Stanley, Gail K, Mattson, Michael, Kozlowski, Meredith, Arcuri, Ildiko, Antal-Zimanyi   +13 more
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Neuropeptide Y as a partial agonist of the Y1 receptor

European Journal of Pharmacology, 2005
In absence of receptor cycling, human/rat neuropeptide Y was found to persistently occupy the guinea pig neuropeptide Y Y1 receptors expressed on the surface of Chinese hamster ovary (CHO) cells (IC50 approximately 8 nM); a lasting occupancy was also evident with active receptor cycling.
Renu, Sah, Ambikaipakan, Balasubramaniam, Michael S, Parker, Floyd, Sallee, Steven L, Parker   +4 more
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The control of bone remodeling by neuropeptide Y receptors

Peptides, 2007
An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice.
S J, Allison, P A, Baldock, H, Herzog
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Neuropeptide Y Y1 receptors in vascular pharmacology

European Journal of Pharmacology, 1998
The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.
A, Franco-Cereceda, J, Liska
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