Results 271 to 280 of about 40,251 (303)

Modulation of neuropeptide Y receptors for the treatment of obesity

Expert Opinion on Therapeutic Patents, 2009
Neuropeptide Y (NPY) has been demonstrated to have critical roles in the physiological control of appetite and energy homeostasis through NPY Y1, Y2, Y4 and Y5 receptors. A number of synthetic ligands for NPY receptor subtypes have been developed to date, with Y5 receptor antagonists and Y2 and Y4 receptor agonists advancing into clinical trials.A ...
Nagaaki, Sato, Yoshio, Ogino, Satoshi, Mashiko, Makoto, Ando   +3 more
openaire   +2 more sources

Sequence and Expression of a Neuropeptide Y Receptor cDNA

Molecular Pharmacology, 1991
The polymerase chain reaction was used to isolate novel GTP-binding protein (G protein)-coupled receptors from bovine locus coeruleus (LC), a brain region enriched in the neuropeptide Y (NPY) system, using degenerate primers derived from the third and sixth transmembrane domains of known G protein-coupled receptors.
J, Rimland, W, Xin, P, Sweetnam, K, Saijoh, E J, Nestler, R S, Duman   +5 more
openaire   +2 more sources

Neuropeptide Y Receptor in Vascular Smooth Muscle

Journal of Neurochemistry, 1991
Abstract: 125I‐Bolton‐Hunter (125I‐BH) neuropeptide Y (NPY) was used to identify specific high‐affinity NPY binding sites in porcine aortic smooth muscle membrane fractions and to characterize the binding sites in comparison with those in porcine hippocampal membrane fractions.
Y, Shigeri, S, Mihara, M, Fujimoto
openaire   +2 more sources

Neuropeptide Y Receptor Subtypes, Y1 and Y2

Annals of the New York Academy of Sciences, 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE ...
C, Wahlestedt, L, Grundemar, R, Håkanson, M, Heilig, G H, Shen, Z, Zukowska-Grojec, D J, Reis   +6 more
openaire   +2 more sources

Neuropeptide Y receptor antagonists

Expert Opinion on Therapeutic Patents, 1999
On the basis of pharmacological observations, neuropeptide Y (NPY) has been implicated to be involved in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for NPY antagonists in disorders such as anxiety, appetite stimulation, obesity, alcohol intake, hypertension, and regulation of coronary tone. This review will
openaire   +1 more source

Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor

European Journal of Pharmacology, 1996
To elucidate which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation of the noradrenaline-evoked contraction in human omental arteries we used antisense oligodeoxynucleotide (Antisense), the new selective neuropeptide Y Y1 receptor antagonist, BIBP3226 {(R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-D ...
A, Bergdahl, T, Nilsson, L, Cantera, L, Nilsson, X Y, Sun, T, Hedner, D, Erlinge, S, Valdemarson, L, Edvinsson   +8 more
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Pharmacology of neuropeptide Y receptor antagonists

European Journal of Pharmacology, 2002
Neuropeptide Y is one of the most abundant mammalian neuropeptides identified to date. The possible actions of neuropeptide Y, that is co-localized and released with noradrenaline, as a sympathetic co-transmitter has attracted much attention during the ...
Malmström, RE
openaire   +2 more sources

Prejunctional Neuropeptide Y Receptors in Human Kidney and Atrium

Journal of Cardiovascular Pharmacology, 1997
The aim of our study was to characterize functionally prejunctional neuropeptide Y (NPY) receptors in human and rabbit renal cortex, as well as in human right atrium. Segments of human atrial appendages and of human and rabbit renal cortex were preincubated with [3H]noradrenaline, superfused with Krebs-Henseleit solution and stimulated electrically in ...
Rump, Lars Christian, Riess, Matthias, Schwertfeger, Eckhard, Michel, Martin C., Bohmann, Christine, Schollmeyer, Peter J.   +5 more
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Neuropeptide Y receptor antagonists.

IDrugs : the investigational drugs journal, 2005
A review of the patent literature for neuropeptide Y (NPY) antagonists is presented for the period of January 2000 to March 2001. This review focuses on antagonists of the Y(1) and Y(5) receptor subtypes, which have been of primary interest as anti-obesity agents.
openaire   +1 more source

Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues

Progress in Neurobiology, 1992
Y, Dumont, J C, Martel, A, Fournier, S, St-Pierre, R, Quirion   +4 more
openaire   +2 more sources