Results 211 to 220 of about 206,103 (264)

Quantitative densitometry of neurotransmitter receptors

Journal of Neuroscience Methods, 1982
An autoradiographic procedure is described that allows the quantitative measurement of neurotransmitter receptors by optical density readings. This procedure is a modification of the method of Young and Kuhar (1979a). Frozen brain sections are labeled in vitro with [3H]ligands under conditions that maximize specific binding to neurotransmitter ...
T C, Rainbow, W V, Bleisch, A, Biegon, B S, McEwen   +3 more
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Neurotransmitter receptors as targets for pesticides

Journal of Environmental Science and Health, Part B, 1983
Nicotinic and muscarinic acetylcholine (ACh) receptors have been identified biochemically by means of their specific binding of [3H] alpha-bungarotoxin ([3H]alpha-BGT) and [3H]quinuclidinyl benzilate, respectively. There are some differences in the drug specificities, and sensitivities to active group reagents, of these receptors in insects when ...
M E, Eldefrawi, A T, Eldefrawi
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Neurotransmitters: Elusive glutamate receptors

Current Biology, 1994
Kainate-preferring glutamate receptors appear to be abundant in the central nervous system. We have recently begun to understand their properties, but their functions remain to be described.
D, Feldmeyer, S, Cull-Candy
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Cetirizine: Actions on neurotransmitter receptors

Journal of Allergy and Clinical Immunology, 1990
First-generation H1-antagonist antihistamines, such as hydroxyzine, have the ability to cross the blood-brain barrier and cause sedation, which limits their usefulness in the treatment of allergic disorders. Cetirizine, a carboxylated metabolite of hydroxyzine, possesses the parent compound's antihistaminic activity but causes less sedation.
A M, Snowman, S H, Snyder
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Neurotransmitter receptor plasticity in aging

Life Sciences, 1994
Neurotransmitter receptor plasticity is an important part of the compensatory processes by which the central nervous system adapts to pathological insult, long-term exposure to drugs or neuronal loss with advanced age. Receptor plasticity can be manifest as changes in the number of receptors (i.e., up- or down-regulation), changes in expression of mRNA
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Receptors, Neurotransmitters and Drug Responses

New England Journal of Medicine, 1979
ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine.
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Inborn errors of neurotransmitter receptors

Journal of Inherited Metabolic Disease, 1999
AbstractInborn errors of neurotransmitter receptors are recently described gene mutations that directly affect receptor function. Currently three conditions are known to be caused by this mechanism: hyperekplexia; two forms of congenital inherited myasthenic syndromes; and autosomal dominant nocturnal frontal lobe epilepsy.
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Drug and Neurotransmitter Receptors in the Brain

Science, 1984
Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism.
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Multiple Neurotransmitter Receptors

Journal of Neurochemistry, 1980
S H, Snyder, R R, Goodman
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Receptors for neurotransmitters and related substances

Current Opinion in Biotechnology, 1991
Advances in techniques for cloning neurotransmitter receptors have revealed new targets for selective drug design. Cell systems for more efficient expression of cloned receptor genes have also been developed. Knowledge of the nature of ligand-binding sites is now becoming available and this should aid in the design of better drugs with fewer side ...
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