Results 111 to 120 of about 2,915 (172)
Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines
Environmental Toxicology and Chemistry, EarlyView.Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz +4 more
wiley +1 more source
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
Genome Editing Technologies to Improve Health‐Related Phytocompounds in Crops
Food Frontiers, EarlyView.ABSTRACT Due to rapid global population growth and the resulting significant increase in food demand, the world is facing an epidemic of malnutrition. Although yield improvement remains one of the main targets of breeding programs, much attention is being paid to the nutritional aspects of crops, including nutrients and bioactive compounds that are ...
Maria Dellino +4 more
wiley +1 more source
Effect of E-cigarette Use and Social Network on Smoking Behavior Change: An agent-based model of E-cigarette and Cigarette Interaction [PDF]
arXiv, 2019 Despite a general reduction in smoking in many areas of the developed world, it remains one of the biggest public health threats. As an alternative to tobacco, the use of electronic cigarettes (ECig) has been increased dramatically over the last decade. ECig use is hypothesized to impact smoking behavior through several pathways, not only as a means of
arxiv
Anxious Dads and Depressed Moms: Child Disability and the Mental Health of Parents
Health Economics, EarlyView.ABSTRACT Having a child with a disability undoubtedly affects parents in many ways, including their well‐being. However, the specific mental health trajectories of parents, differentiated by the severity of impairments and parental roles, remain under‐explored. We investigate the mental‐health effects of having a child with a disability.
Derek Asuman +2 more
wiley +1 more source
Guidance for Introducing the Tobacco‐Free Generation Policy
The International Journal of Health Planning and Management, EarlyView.ABSTRACT This article serves as a guide to the Tobacco‐Free Generation policy (TFG) for policy‐makers, drawing on experiences of negotiations regarding TFG in a wide number of jurisdictions. It explains the underlying concept: the highly addictive nature of nicotine prompts policy focus on preventing initial use by forbidding sales to those born after ...
Jon Berrick
wiley +1 more source
Research progress on the mechanisms of pain empathy
Ibrain, EarlyView.This article is related to the graphical research progress of pain empathy, starting with the description of the pain matrix and mirror neurons. Based on the pain matrix and mirror neurons, pain empathy results from the combined action of brain regions such as the anterior cingulate cortex, insula, prefrontal cortex, and amygdala and regulatory ...
Shuangshuang Liu +5 more
wiley +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules +4 more
wiley +1 more source
Multi‐cycle high‐throughput growth media optimization using batch Bayesian optimization
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND The optimization of growth media is a crucial step in enhancing microbial growth and product formation in industrial bioprocesses. While Design of Experiments (DoE) is widely used for this purpose, it has inherent limitations, particularly in capturing complex interactions between media components and managing the high number of ...
Frédéric M. Lapierre +5 more
wiley +1 more source
Non‐Tobacco Nicotine Use and Complications in Free Flap Repair in Head and Neck Cancer
The Laryngoscope, EarlyView.Non‐tobacco nicotine use is associated with an increased risk of postoperative complications in HNC patients following free flap reconstruction. ABSTRACT Objective Assess associations between non‐tobacco nicotine usage and free flap repair complications in head and neck cancer (HNC) patients.
Asher C. Park +6 more
wiley +1 more source