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Effect of nicotine and nicotinic receptors on anxiety and depression
Neuroreport, 2002Nicotine has been shown to have effects on anxiety and depression in both human and animal studies. These studies suggest that nicotinic acetylcholine receptors (nAChRs) can modulate the function of pathways involved in stress response, anxiety and depression in the normal brain, and that smoking can result in alterations of anxiety level and mood. The
Marina R, Picciotto +2 more
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Nicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders
Archives of Medical Research, 2000Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-gated cation channels with diverse structures and properties. In contrast to the muscular nAChRs, the physiological functions of neuronal nAChRs are not well defined to date.
S, Mihailescu, R, Drucker-Colín
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
Cell, 2021Steven Sine +2 more
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Nicotinic receptors and stages of nicotine dependence.
Journal of psychopharmacology (Oxford, England), 2010Smoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. Consequently, there have been extensive investigations into the neuroadaptations that occur as nicotine dependence develops, where numerous neurological systems have been implicated. The focus of this review was
K A, Brennan +3 more
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Nicotinic Acid: Pharmacological Effects and Mechanisms of Action
Annual Review of Pharmacology and Toxicology, 2008Andreas Gille +2 more
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Effects of nicotinic stimulation on cognitive performance
Current Opinion in Pharmacology, 2004Alexandra Potter, Paul Newhouse
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