Results 111 to 120 of about 46,003 (163)

Schizophrenia and Nicotinic Receptors

Harvard Review of Psychiatry, 1994
Patients with schizophrenia often cannot respond to important features of their environment and filter out irrelevant stimuli. This dysfunction could be related to an underlying defect in inhibition--i.e., the brain's ability to alter its sensitivity to repeated stimuli. One of the neuronal mechanisms responsible for such inhibitory gating involves the
Robert Freedman, Lawrence E. Adler, Paula Bickford, William Byerley, Hilary Coon, Munro C. Cullum, Jay M. Griffith, Josette G. Harris, Sherry Leonard, Christine Miller, Marina Myles-Worsley, Herbert T. Nagamoto, Greg Rose, Merilyne Waldo   +13 more
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Nicotinic receptors and schizophrenia

Current Medical Research and Opinion, 2004
The incidence of smoking is very high in non-schizophrenic subjects presenting various psychiatric disorders (35 to 54%). However, the incidence of smoking is extremely high in schizophrenic patients: 80% to 90%, versus 25% to 30% of the general population. Various studies have demonstrated that the use of tobacco transiently restores the schizophrenic
Nadège, Ripoll, Marie, Bronnec, Michel, Bourin   +2 more
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The Nicotinic Receptor Genes

Clinical Neuropharmacology, 1991
The causative factor(s) of Alzheimer's disease (AD) are presently unknown. However, it has been shown that the number as well as the fraction of high- to low-affinity nicotine binding sites is altered in patients suffering from this disease. This finding, along with the identification of seven genes which code for nicotinic receptors expressed in the ...
S. Heinemann, J. Boulter, J. Connolly, E. Deneris, R. Duvoisin, M. Hartley, I. Hermans-Borgmeyer, M. Hollmann, A. OʼShea-Greenfield, R. Papke, S. R ogers, J. Patrick   +11 more
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Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders

Current Topics in Medicinal Chemistry, 2004
Advances in the understanding of the neurobiology of the nicotinic receptor have started to be matched by an appreciation of the potential role of these receptors in a variety of neuropsychiatric disorders. While alterations in nicotinic receptor number and/or function have been associated with such conditions as Alzheimer's disease for several years ...
Paul, Newhouse, Abhay, Singh, Alexandra, Potter   +2 more
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Nicotine and Nicotinic Receptors; Relevance to Parkinson’s Disease

NeuroToxicology, 2002
The development of nicotinic agonists for therapy in neurodegenerative disorders such as Parkinson's disease is an area currently receiving considerable attention. The rationale for such work stems from findings that reveal a loss of nicotinic receptors in Parkinson's disease brains.
Maryka, Quik, Jennifer M, Kulak
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Structure of Neuronal Nicotinic Receptors

2015
Nicotinic acetylcholine receptors (nAChRs) are a critical component of the brain's cholinergic neurotransmission system that modulates important physiological processes and whose dysfunction has been observed in patients with neurodegenerative diseases and mental illness.
Fasoli F, Gotti C
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Nicotinic Receptors and Attention

2015
Facilitation of different attentional functions by nicotinic acetylcholine receptor (nAChR) agonists may be of therapeutic potential in disease conditions such as Alzheimer's disease or schizophrenia. For this reason, the neuronal mechanisms underlying these effects have been the focus of research in humans and in preclinical models.
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