Results 151 to 160 of about 2,426,956 (334)

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source

Lynx1 and the family of endogenous mammalian neurotoxin-like proteins and their roles in modulating nAChR function

Pharmacological Research, 2023
The promise of nicotinic receptors as a therapeutic target has yet to be fully realized, despite solid data supporting their involvement in neurological and neuropsychiatric diseases.
Talulla B. Palumbo, Julie.M. Miwa
doaj  

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core  

Multi‐cycle high‐throughput growth media optimization using batch Bayesian optimization

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The optimization of growth media is a crucial step in enhancing microbial growth and product formation in industrial bioprocesses. While Design of Experiments (DoE) is widely used for this purpose, it has inherent limitations, particularly in capturing complex interactions between media components and managing the high number of ...
Frédéric M. Lapierre, Pasquale Mattaliano, Dennis Raith, Mariela Castillo‐Cota, Jonas Bermeitinger, Robert Huber   +5 more
wiley   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Effect of smoking over one pack daily on implant healing and health: A cohort study

Journal of Periodontology, EarlyView.
Abstract Background This prospective cohort trial examines the effects of heavy smoking on peri‐implant marginal bone loss (MBL) and implant survival rates over 15 months. Methods Thirty subjects, categorized as either smokers (more than 20 cigarettes daily for over 5 years) or non‐smokers, were initially recruited with pocket depths ≤ 5 mm and at ...
Yaniv Mayer, Eran Gabay, Eli E. Machtei, Eli Regev, Ofir Ginesin, Zvi Gutmacher, Jacob Horwitz, Luigi Canullo, Jamil Awad Shibli, Hadar Giladi Zigdon   +9 more
wiley   +1 more source

Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core   +1 more source

Non‐Tobacco Nicotine Use and Complications in Free Flap Repair in Head and Neck Cancer

The Laryngoscope, EarlyView.
Non‐tobacco nicotine use is associated with an increased risk of postoperative complications in HNC patients following free flap reconstruction. ABSTRACT Objective Assess associations between non‐tobacco nicotine usage and free flap repair complications in head and neck cancer (HNC) patients.
Asher C. Park, Larry Wang, Milan P. Fehrenbach, Oluwatobiloba Ayo‐Ajibola, Urjeet A. Patel, Sandeep Samant, Katelyn O. Stepan   +6 more
wiley   +1 more source