Results 151 to 160 of about 2,466,892 (329)

Modulating Neurotoxic Effects of Prenatal Chlorpyrifos Exposure Through Probiotic and Vitamin D Gestational Supplementation: Unexpected Effects on Neurodevelopment and Sociability

Food Frontiers, EarlyView.
This study investigates whether gestational probiotic and vitamin D supplementation can mitigate CPF effects in Wistar rats. While supplementation did not reverse CPF‐induced deficits, it induced notable neurodevelopmental changes in control animals, underscoring the need for further research on prenatal supplementation safety.
Mario Coca, Cristian Perez‐Fernandez, Ana C. Abreu, Ana M. Salmerón, Miguel Morales‐Navas, Diego Ruiz‐Sobremazas, Teresa Colomina, Ignacio Fernández, Fernando Sanchez‐Santed   +8 more
wiley   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, EarlyView.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

Vanillin Modulates the Sedative Effect of Diazepam, Possibly Through GABAergic Interaction Pathways in Thiopental Sodium‐Induced Sleeping Mice

Food Safety and Health, EarlyView.
Vanillin showed moderate sedative and modulatory synergistic activities on diazepam in thiopental sodium‐induced sleeping mice. These effects are implicated with GABAergic intervention. ABSTRACT Insomnia is a common sleep disorder affecting approximately 10% of adults.
Salehin Sheikh, Md. Shimul Bhuia, Raihan Chowdhury, Md. Sakib Al Hasan, Most. Israt Jahan Oni, Imam Hossen Rakib, Mir Imran Alim, Jakia Sultana, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Variations in “Functional Site” Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Toxins
Three-finger toxins (3FTxs) are the largest group of nonenzymatic toxins found in snake venoms. Among them, neurotoxins that target nicotinic acetylcholine receptors are the most well-studied ligands.
R. Manjunatha Kini, Cho Yeow Koh
doaj   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, EarlyView.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

FEBS Letters, 2018
Arik J. Hone, J. M. McIntosh
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Retaining infants and young children who experience transitions in care in longitudinal studies of child health and development: Considerations from the HEALthy Brain and Child Development study

Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.
Abstract A transition in care (TIC) is a significant change in the primary adults who provide care for a child, involving a move to informal or formal non‐parental care, including kinship and foster care. In this paper, we address three issues: (1) the theoretical and empirical reasons for retaining infants and children who experience TIC in ...
Julie Poehlmann, Elizabeth I. Johnson, Pilar N. Ossorio, Keisher Highsmith, Brenda Jones Harden, Mishka Terplan, Pilar M. Sanjuan, Lorraine McKelvey, Claire D. Coles, Barbara H. Chaiyachati, Hon. Peggy Walker, Rebecca Shlafer, Kaitlyn Pritzl, Chandni Anandha Krishnan, Stephanie Averill, Samir Das, Santiago Torres‐Gomez, Florence Hilliard, Brian Gannon, Wesley K. Thompson   +19 more
wiley   +1 more source

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation

iMetaOmics, EarlyView.
Microbiota‐gut‐brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood‐brain barrier (BBB), and brain. This integrated platform incorporates neural (blue), endocrine (yellow), immune (pink), and metabolic (green) pathways to investigate the impact ...
Yue Tang, Hewen Chen, Ziyue Zhao, Xuesong Kang, Wenxin Wang, Kun Dai, Yufei Guo, Axin Liang, Aiqin Luo, Zikai Hao   +9 more
wiley   +1 more source