Results 191 to 200 of about 2,426,956 (334)

Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors.

Nature Chemistry, 2012
Ivan Tochitsky, Matthew R. Banghart, A. Mourot, Jennifer Z Yao, Benjamin M. Gaub, R. Kramer, D. Trauner   +6 more
semanticscholar   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Cerebral Blood Flow Responses to Trigeminal Olfactory Stimulation and Their Nicotinic Cholinergic Regulation in Anesthetized Rats. [PDF]

Eur J Neurosci
Morihara D, Moriya J, Kagitani F, Uchida S.   +3 more
europepmc   +1 more source

Augmentation of cognitive function by NS9283, a stoichiometry‐dependent positive allosteric modulator of α2‐ and α4‐containing nicotinic acetylcholine receptors

British Journal of Pharmacology, 2012
D. Timmermann, K. Sandager‐Nielsen, T. Dyhring, M. Smith, Jacobsen Am, E. Nielsen, M. Grunnet, Jeppe Kejser Christensen, D. Peters, K. Kohlhaas, Gunnar Olsen, P. Ahring   +11 more
semanticscholar   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

α7-Nicotinic Acetylcholine Receptor and Mutated α-Synuclein Interact in Motor Behaviour and Nigrostriatal Dopamine-Findings With Potential Relevance for a Protective Effect of Cigarette Smoking and Parkinson's Disease. [PDF]

Eur J Neurosci
Pifl C, Wolf A, Elevado M, Scholze P.
europepmc   +1 more source

CD38‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice

Aging Cell, EarlyView.
Shangcheng Yu et al. revealed that CD38‐targeting peptide vaccine ameliorated aging‐associated physical and cognitive phenotypes in mice. CD38‐vaccine selectively depletes CD38+ myeloid cells, improves glucose tolerance, and enhances oxygen consumption.
Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen, Haiteng Deng   +10 more
wiley   +1 more source

The Role of α7-Nicotinic Acetylcholine Receptors in the Pathophysiology and Treatment of Parkinson's Disease. [PDF]

Int J Mol Sci
ElNebrisi E, Lozon Y, Oz M.
europepmc   +1 more source

An ecological momentary assessment study of predictors for alcohol outcomes in transgender and gender diverse youth

Alcohol, Clinical and Experimental Research, EarlyView.
In this study, we demonstrate that on days or moments when transgender and gender diverse (TGD) youth experience increased gender minority stressors, they also report increased alcohol use, alcohol craving, and psychological distress, as well as coping motives.
Sarah S. Dermody, Stephanie M. Penta, Theodore Forest Quinn, Alexandra Uhrig, Jeffrey D. Wardell, Trevor A. Hart, Christian S. Hendershot, Elizabeth Saewyc, Alex Abramovich   +8 more
wiley   +1 more source

Use of Antidepressants Decreased After Initiation of ADHD Treatment in Adults—A Finnish Nationwide Register Study Describing Use of ADHD and Non‐ADHD Medication in People With and Without ADHD

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction ADHD is often associated with comorbid psychiatric conditions. Differential diagnosis between other conditions and ADHD is not always clear, and patients are sometimes initially treated for another disorder instead. ADHD diagnosis and appropriate ADHD treatment potentially reduce the need for medication of the other disorder ...
Elisa Westman, Tuire Prami, Alvar Kallio, Ilona Iso‐Mustajärvi, Joel Jukka, Paavo Raittinen, Maarit J. Korhonen, Anita Puustjärvi, Sami Leppämäki   +8 more
wiley   +1 more source