Results 251 to 260 of about 2,394,761 (293)

Nicotine and Nicotinic Receptors; Relevance to Parkinson’s Disease

NeuroToxicology, 2002
The development of nicotinic agonists for therapy in neurodegenerative disorders such as Parkinson's disease is an area currently receiving considerable attention. The rationale for such work stems from findings that reveal a loss of nicotinic receptors in Parkinson's disease brains.
Maryka Quik, Jennifer M. Kulak
openaire   +2 more sources

Nicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders

Archives of Medical Research, 2000
Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-gated cation channels with diverse structures and properties. In contrast to the muscular nAChRs, the physiological functions of neuronal nAChRs are not well defined to date.
René Drucker-Colín, Stefan Mihailescu
openaire   +3 more sources

Effect of nicotine and nicotinic receptors on anxiety and depression

Neuroreport, 2002
Nicotine has been shown to have effects on anxiety and depression in both human and animal studies. These studies suggest that nicotinic acetylcholine receptors (nAChRs) can modulate the function of pathways involved in stress response, anxiety and depression in the normal brain, and that smoking can result in alterations of anxiety level and mood. The
Barbara J. Caldarone, Marina R. Picciotto, Darlene H. Brunzell   +2 more
openaire   +3 more sources

Structure of Neuronal Nicotinic Receptors

2015
Nicotinic acetylcholine receptors (nAChRs) are a critical component of the brain's cholinergic neurotransmission system that modulates important physiological processes and whose dysfunction has been observed in patients with neurodegenerative diseases and mental illness.
Fasoli F, Gotti C
openaire   +4 more sources

Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
openaire   +3 more sources

Human neuronal nicotinic receptors

Progress in Neurobiology, 1997
Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative, behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptors (NAChRs). These receptors are distributed widely in human brain and ganglia, and form a family of ACh-gated ion channels of different subtypes, each of which has a ...
C. Gotti, D. Fornasari, F. Clementi
openaire   +4 more sources

Nicotinic Receptors and Attention

2015
Facilitation of different attentional functions by nicotinic acetylcholine receptor (nAChR) agonists may be of therapeutic potential in disease conditions such as Alzheimer's disease or schizophrenia. For this reason, the neuronal mechanisms underlying these effects have been the focus of research in humans and in preclinical models.
openaire   +3 more sources

Nicotinic receptors in wonderland

Trends in Biochemical Sciences, 2001
Abstract The structure of a soluble homopentameric homologue of the N-terminal extracellular domain of the nicotinic acetylcholine (ACh) receptor has recently been determined at the atomic level. These data reveal the three-dimensional structure of the binding site for ACh and nicotinic ligands.
Jean-Pierre Changeux, Thomas Grutter
openaire   +2 more sources

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

Trends in Pharmacological Sciences, 1990
Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
openaire   +3 more sources

Nicotinic Receptors

2012
Publisher Summary This chapter focuses on the structural considerations and subtype diversity of nicotinic receptors. Nicotinic receptors assemble as pentamers of individual subunits. Assembly occurs in a precise manner and order such that the assembled subunits encircle an internal membrane pore and the extracellular vestibule leading to the pore ...
openaire   +2 more sources