Results 251 to 260 of about 2,426,956 (334)

An unusual case of airway edema and encephalopathy: imidacloprid poisoning. [PDF]

World J Emerg Med
Mathew M, M Nair S, G N, Rose Paul N.
europepmc   +1 more source

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Elucidating the role of peripheral monocyte nicotinic acetylcholine receptors and inflammation in cognitive outcomes in older adults. [PDF]

Biogerontology
Kohn JN, Ang G, Pruitt C, Gandarilla I, Tu X, Hong S.   +5 more
europepmc   +1 more source

Examining the Likelihood of Being Referred to the Child Welfare Services in Sweden: Influences at the Individual, Peer and School‐Area Levels

Child &Family Social Work, EarlyView.
ABSTRACT In Sweden, both maltreatment and behavioural problems are indicative of needs that motivate interventions from child welfare services (CWS). However, the likelihood of being referred to CWS can be influenced by other than indicative factors on individual, peer and school‐area levels.
Torbjörn Kalin
wiley   +1 more source

Diverse toxins exhibit a common binding mode to the nicotinic acetylcholine receptors. [PDF]

Biophys J
Do HN, Kubicek-Sutherland JZ, Gnanakaran S.   +2 more
europepmc   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells. [PDF]

Diabetes
Hamilton A, Zhang Q, Gao R, Hill TG, Salehi A, Knudsen JG, Draper MB, Johnson PRV, Rorsman P, Tarasov AI.   +9 more
europepmc   +1 more source

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

Cell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li, Bo Chen, Sibo Sun, Kai Wang, Yu Wang, Jianqing Wu   +5 more
wiley   +1 more source

A Pharmacophore for Drugs Targeting the α4α4 Binding Site of the (α4)₃(β2)₂ Nicotinic Acetylcholine Receptor. [PDF]

J Neurochem
Kusay AS, Luo Y, O'Mara ML, Balle T.
europepmc   +1 more source