NICOTINIC RECEPTORS IN NEUROPSYCHIATRIC PATHOLOGIES OF ADULTHOOD AND DEVELOPMENTAL AGE. [PDF]
Euromediterranean Biomedical Journal, 2013 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels present in many regions of the central nervous system (CNS) and the peripheral nervous system.
Elettra Unti
doaj +1 more source
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine [PDF]
, 2015 Glutamate receptors sensitive to N-methyl-d-aspartate (NMDA) are involved in embryonic brain development but their activity may be modulated by the kynurenine pathway of tryptophan metabolism which includes an agonist (quinolinic acid) and an antagonist (
Darlington, L.G. +5 more
core +1 more source
Current Neuropharmacology, 2018 Background Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to α7 nAChRs in a perspective of pain and its ...
D. Bagdas +4 more
semanticscholar +1 more source
Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures [PDF]
, 2012 We exploit the optical and spatial features of subwavelength nanostructures to examine individual receptors on the plasma membrane of living cells. Receptors were sequestered in portions of the membrane projected into zero-mode waveguides.
Dougherty, Dennis A. +6 more
core +1 more source
Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia.
Nicotine & Tobacco Research, 2018 While current treatments for schizophrenia often provide much relief for positive symptoms such as hallucinations, other symptoms, particularly cognitive deficits, persist and contribute to substantial suffering and reduced quality of life for patients ...
J. Tregellas, Korey P. Wylie
semanticscholar +1 more source
Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report
Clinical Practice and Cases in Emergency Medicine, 2020 Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear +4 more
doaj +1 more source
Nicotine inhibits memory CTL programming. [PDF]
PLoS ONE, 2013 Nicotine is the main tobacco component responsible for tobacco addiction and is used extensively in smoking and smoking cessation therapies. However, little is known about its effects on the immune system.
Zhifeng Sun +5 more
doaj +1 more source
Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus [PDF]
, 2001 Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to ...
Alan Fine +6 more
core +1 more source
Mammalian nicotinic acetylcholine receptors: from structure to function.
Physiological Reviews, 2009 The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of a "receptor" came to light.
E. Albuquerque +3 more
semanticscholar +1 more source
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease [PDF]
, 1993 Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects.
Jenner, P. +3 more
core +1 more source