Results 81 to 90 of about 2,915 (172)

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions

Pharmacological Research, 2023
Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
doaj  

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

Drug use over time among never‐deployed US Army Reserve and National Guard soldiers: The longitudinal effects of non‐deployment emotions and sex

Stress and Health, Volume 38, Issue 5, Page 1045-1057, December 2022., 2022
Abstract Some US military service members who have never been deployed experience negative emotions related to never having been deployed, and some work shows these non‐deployment emotions (NDE) are cross‐sectionally associated with hazardous drinking for male, but not female, US Army Reserve/National Guard (USAR/NG) soldiers.
Rachel A. Hoopsick, D. Lynn Homish, Schuyler C. Lawson, Gregory G. Homish   +3 more
wiley   +1 more source

Characterization of nAChRs in Nematostella vectensis supports neuronal and non-neuronal roles in the cnidarian–bilaterian common ancestor

EvoDevo, 2019
Background Nicotinic and muscarinic acetylcholine receptors likely evolved in the cnidarian–bilaterian common ancestor. Both receptor families are best known for their role at chemical synapses in bilaterian animals, but they also have described roles as
Dylan Z. Faltine-Gonzalez, Michael J. Layden   +1 more
doaj   +1 more source

Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]

arXiv, 2018
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv  

A review of frequently used Kampo prescriptions part 1. Daikenchuto

Traditional &Kampo Medicine, Volume 9, Issue 3, Page 151-179, December 2022., 2022
Abstract Background The original formula name for daikenchuto (DKT) was written in ‘Jin Gui Yao Lue (Kinkiyōryaku in Japanese)’. DKT as used in Japan consists of four types of crude drug. Key findings Although there are few examples of its use in Chinese classical records, it has begun to be used extensively in modern Japan for intestinal obstruction ...
Takao Namiki, Takayuki Hoshino, Nobuaki Egashira, Toshiaki Kogure, Mari Endo, Masato Homma   +5 more
wiley   +1 more source

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

PLoS ONE, 2014
Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin   +9 more
doaj   +1 more source

A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison, Joelle Batonga, Thangam Arumugham, Angela Bartkus, Marion Morrison, Mark J. Mullin, Tim Tippin, Odin Naderer   +7 more
wiley   +1 more source

Impact of dietary supplementation of unsaturated and saturated fatty acids on bone strength, fatty acids profile of thigh muscle and immune responses in broiler chickens under heat stress

Veterinary Medicine and Science, Volume 9, Issue 1, Page 252-262, January 2023., 2023
Results suggest that there is not beneficial effect of broiler performance due to adding different source of fat in broiler chicken diet under hot condition. Furthermore, the unsaturated fatty acids could improve profile of fatty acids in thigh and enhance immune responses in broiler chickens.
Reza Vakili, Yahya Ebrahimnezhad
wiley   +1 more source

Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]

arXiv, 2009
To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv