Results 131 to 140 of about 83,214 (263)

Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of Azadirachta indica Phytoconstituents Using In Vitro and In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico methodologies. Sarcoptes scabiei were stimulated with Azadirachta indica at four concentrations (25–100 mg/mL) at different intervals.
Tehreem Fatima, Mazhar Abbas, Kinza Zafar, Maha Gul Zafar, Waqas Haider, Muhammad Haseeb Zafar, Muhammad Riaz, Munawar Iqbal, Andrew G. Mtewa   +8 more
wiley   +1 more source

Perspectives on Endogenous Opioids in Birds

Frontiers in Physiology, 2018
The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions.
Colin G. Scanes, Krystyna Pierzchala-Koziec   +1 more
doaj   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
core  

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

Scientific Reports, 2018
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat. We have shown previously that spinal application of dipeptidyl peptidase 4 (DPP4) inhibitors induces strong ...
Kornél Király, Márk Kozsurek, Erika Lukácsi, Benjamin Barta, Alán Alpár, Tamás Balázsa, Csaba Fekete, Judit Szabon, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Zsuzsanna E. Tóth, Károly Pap, Gábor Gerber, Zita Puskár   +14 more
doaj   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele, Patricia E. Kunze, Manuela L. Wieser, Annette P. N. Kutter   +3 more
wiley   +1 more source

The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets

Cells
The presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa, Mohammed Shaqura, Sascha Tafelski, Jan David Wandrey, Özgür Celik, Sascha Treskatsch, Michael Schäfer   +6 more
doaj   +1 more source

A Review of Exercise Interventions for Rehabilitation in Drug‐Dependent Individuals

Addiction Biology, Volume 30, Issue 12, December 2025.
The analysis of 39 core studies indicates that diverse exercise interventions have varying positive effects across different dimensions for various addiction populations. Exercise can exert beneficial impacts on the neurobiological mechanisms, as well as physiological and psychological aspects, of individuals with drug addiction.
Qinghua He, Li Zhu, Zhaosong Wang, Hao Wang, Yiyi Jiang, Xin Wang, Fuxuan Luo, Chaoyi Zhu, Changlong Zhan   +8 more
wiley   +1 more source

Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses

Equine Veterinary Education, Volume 37, Issue 12, Page 647-653, December 2025.
Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel, G. L. Hildon, K. M. Coumbe, E. Busuttil, D. von Schweinitz, S. Devereux   +5 more
wiley   +1 more source

Dopaminergic, glutamatergic but not opioidergic mechanisms mediate induction of FOS-like protein by cocaethylene [PDF]

, 1997
Cocaethylene is a psychoactive metabolite formed\ud during the combined consumption of cocaine and ethanol. As\ud this metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of ...
DiPirro, Dr. J.M., Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +3 more
core  

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source