Results 111 to 120 of about 779,673 (234)
Opioid drug seeking after early-life adversity: a role for delta opioid receptors
Addiction NeuroscienceOpioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but the ...
Sophia C. Levis +9 more
doaj +1 more source
Nalfurafine hydrochloride to treat pruritus: a review
Clinical, Cosmetic and Investigational Dermatology, 2015 Shigeki InuiDepartment of Regenerative Dermatology, Osaka University Graduate School of Medicine, Osaka, JapanAbstract: Uremic pruritus has a great negative influence on quality of life in hemodialysis (HD) patients and, importantly, negatively affects ...
Inui S
doaj
Identification of ligand binding determinants in the cloned mouse kappa and delta opioid receptors
, 1995 Endogenous opioid peptides as well as opioid alkaloids exert their biological effects by interacting with a family of membrane-bound receptors. The molecular cloning of the $\kappa, \delta,$ and $\mu$ opioid receptors, which belong to the seven ...
Kong, Haeyoung
core
Ontogenetic studies on mu, delta and kappa opioid receptors in rat brain
, 1986 The ontogenetic pattern of multiple opioid binding sites in rat brain from birth until weaning has been investigated. [3H]-dihydromorphine ([3H]-DHM)3 [3H]-D-Ala2-D-Leu5-enkephalin ([3H]-DADLE) and [3H]-dynorphin A (1-8) ([3H]-DYN) as markers of mu (mu),
C.L. Galli +4 more
core +1 more source
Journal of Pain Research, 2018 Baowen Liu, Yi Liu, Ningbo Li, Jin Zhang, Xianwei Zhang Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Background: Oxycodone, which is one of the most commonly used ...
Liu BW, Liu Y, Li NB, Zhang J, Zhang XW
doaj
Extraordinary postmortem stability of kappa opioid receptors in guinea-pig brain
, 1987 Postmortem delay can be an important variable in biochemical studies on autopsy tissue. We subjected guineapig brains to gradual cooling, simulating temperature conditions of human postmortem brains, in order to assess the sensitivity of kappa receptors ...
Carlo Ori +3 more
core +1 more source
Frontiers in PharmacologyIntroductionKratom (Mitragyna speciosa) contains over 50 alkaloids, yet the pharmacological activity of most remains poorly defined, limiting our understanding of its therapeutic potential and safety profile.MethodsWe conducted a comprehensive evaluation
S. E. Hemby +7 more
doaj +1 more source
Molecular recognition at kappa opioid receptors*
, 2001 : Structure-activity relationships are rarely straightforward, and often are more complicated than they appear. For this reason, the use of site-directed mutagenesis as a complementary tool to analyze structure-activity relationships has been invaluable.
Philip S Portoghese
core
Kappa Opioid Receptor Expression by Macrophages
The endogenous opioid system includes three primary opioid receptors: the mu, delta, and kappa opioid receptors. Each is a G-protein-coupled receptor expressed on the exterior membrane of diverse cell types, with neuronal cells having been the most ...
Reed, Brian
core +1 more source
NOCICEPTIN/ORPHANIN FQ RECEPTOR LIGANDS: PHARMACOLOGICAL STUDIES [PDF]
, 2009 The neuropeptide nociceptin/orphanin FQ (N/OFQ) selectively binds and activates the N/OFQ peptide (NOP) receptor. At cellular level N/OFQ inhibits cAMP accumulation and Ca2+ conductance and stimulates K+ currents.
Fischetti, Carmela +1 more
core