Results 101 to 110 of about 779,673 (234)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

The Identification of Opioid Receptors and Peptide Precursors in Human DRG Neurons Expressing Pain-Signaling Molecules Confirms Their Potential as Analgesic Targets

Cells
The presence and function of the opioidergic system in sensory dorsal root ganglia (DRG) was demonstrated in various animal models of pain. To endorse recent functional and transcriptional evidence of opioid receptors in human DRG, this study compared ...
Shaaban A. Mousa, Mohammed Shaqura, Sascha Tafelski, Jan David Wandrey, Özgür Celik, Sascha Treskatsch, Michael Schäfer   +6 more
doaj   +1 more source

Assessing the Concurrent Validity of the Australian Treatment Outcomes Profile in a Methamphetamine Dependent Treatment‐Seeking Population

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool assessing substance use, health and well‐being used in Australian alcohol and other drug treatment services. It is validated for use with clients using alcohol, opioids and cannabis, but not yet for clients who primarily use methamphetamine.
Brendan Clifford, Rachel M. Deacon, Kristie Mammen, Krista J. Siefried, Nadine Ezard, Nicholas Lintzeris   +5 more
wiley   +1 more source

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2623-2638, September 2026.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

Distribution of kappa opioid receptors in the brain of young and old male rats

, 1989
The experiments to be described have been designed in order to: (a) provide new information on the concentrations of opioid kappa receptors in different regions of the brain of the male rats; and (b) to analyze whether the density of brain kappa ...
F. Piva, L. Martini, R. Maggi, P. Limonta, D. Dondi   +4 more
core   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Local kappa opioid receptor activation decreases temporomandibular joint inflammation

, 2015
In an attempt to decrease central side effects associated with the use of opioids, some strategies have been developed by targeting peripheral opioid receptors.
Melo, Vilma, Torres-Chávez, Karla E., Chicre-Alcântara, Tânia C., Parada, Carlos Amílcar, Melo, Vilma., Fischer, Luana, Clemente-Napimoga, Juliana T., Tambeli, Claudia Herrera   +7 more
core   +1 more source

Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression

Function
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied.
Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Zheng Xie, Aaron P Fox, Nanduri R Prabhakar   +5 more
doaj   +1 more source

AI-Based Approach To Screen Opioid Receptor Ligands Via Grind Fingerprints and Convolutional Neural Network

Iraqi Journal of Pharmaceutical Sciences
Opioid receptors belong to G-Protein Coupled Receptor (GPCR) family, and are divided into 3 subtypes of Mu, Kappa and Delta. The receptors are targeted by agonists and antagonists to manage variety of medical issues. Although main endogenous ligands for
Mohammed Al-Qattan
doaj   +1 more source

Differential ontogeny of multiple opioid receptors (mu, delta, and kappa)

, 1985
We investigated the postnatal ontogeny of opioid receptors in rat brain under assay conditions which, when combined with computerized analysis, effectively reflect the developmental profile of high affinity binding to mu, delta, and kappa subpopulations.
JW Spain, BL Roth, CJ Coscia
core   +1 more source