Results 81 to 90 of about 779,673 (234)

Opiate-induced analgesia: contributions from mu, delta and kappa opioid receptors mouse mutants

, 2013
The three opioid receptors, mu, delta and kappa all mediate analgesia, and knockout mice with opioid receptor deletion have proven unique tools to investigate in vivo opioid pharmacology.
Gaveriaux-Ruff, Claire
core   +1 more source

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits

, 2022
Modern genetic approaches in animal models have unveiled novel itch-specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions.
Kim, Brian S, Sciascia, Thomas, Szepietowski, Jacek C, Inan, Saadet, Thomas Sciascia, Kim, Brian S., Brian S. Kim, Gil Yosipovitch, Inan|, Sonja Ständer, Ständer, Sonja, Saadet Inan, Szepietowski, Jacek C., Yosipovitch, Gil, Jacek C. Szepietowski   +14 more
core   +1 more source

Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages

Biochemistry and Biophysics Reports
Nalmefene, an antagonist of mu- and delta-opioid receptors and a partial agonist of kappa-opioid receptors, has shown promise in reducing alcohol consumption among patients with alcohol dependence.
Mitsuhisa Koga, Koshun Inada, Ayano Yamada, Kana Maruoka, Atsushi Yamauchi   +4 more
doaj   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 887-892, October 2026.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Stress-evoked opioid release inhibits pain in major depressive disorder [PDF]

, 2008
To determine whether stress-evoked release of endogenous opioids might account for hypoalgesia in major depressive disorder (MDD), the μ-opioid antagonist naltrexone (50 mg) or placebo was administered double-blind to 24 participants with MDD and to 31 ...
Frew, A.K., Drummond, P.D.
core  

Ethnic Differences in Unmet Care Needs Among Cancer Survivors in Utah Using a Mixed Methods Approach

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Cancer survivors' unmet care needs can negatively affect well‐being and quality of life, yet few studies focus on how Hispanic/Latino (Hispanic) survivors' needs may differ from those of non‐Hispanic White (NHW) survivors. Aims To explore unmet needs of cancer survivors by ethnicity.
Sara G. Jackson, Anne C. Kirchhoff, Sandra L. Edwards, Kimberly A. Herget, Marjorie E. Carter, Rachel R. Codden, Blessing S. Ofori‐Atta, Marie Nagata, Carol Sweeney, Morgan M. Millar   +9 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Shan‐shan Hu, Chao‐feng Zhang, Battuvshin Lkhagvasuren, Di Wang   +3 more
wiley   +1 more source

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus

Scientific Reports
Opioid addiction constitutes a significant global health challenge. Kappa opioid receptor (KOP) modulators have demonstrated efficacy in treating resistant drug abuse cases.
Ahmad Abdelwaly, Hesham Safwan, Shamba Chatterjee, Mohamed Elsayed, Khaled M. Darwish, Amar Chittiboyina, Mohamed A. Helal   +6 more
doaj   +1 more source

Naloxone in Buprenorphine Overdose: A Life Saving Intervention [PDF]

Journal of Clinical and Diagnostic Research
Buprenorphine acts as a partial agonist at μ-opioid and ORL-1 (nociceptin) receptors, an antagonist at κ-opioid receptors, and an agonist at σ-opioid receptors.
Aviral Ratan Srivastava, Sarbari Swaika, Tanvi Snehal Desai   +2 more
doaj   +1 more source