Results 61 to 70 of about 779,673 (234)

The risk and resilience factors associated with secondary traumatic stress in school personnel: A scoping review

British Journal of Educational Psychology, EarlyView.
Abstract Background School personnel bear the emotional burden of students' trauma. Secondary traumatic stress (STS), resulting from indirect trauma exposure, impacts well‐being and job performance through PTSD‐like symptoms, making addressing STS in schools a critical priority.
Paul Gordon, Lisa Jane Rodgers, Martin Dempster, Donncha Hanna   +3 more
wiley   +1 more source

Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]

, 2013
There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine, Sarah Koutnik, Inka Regine Weingaertner, Koutnik, Sarah, Hermann Ammer, Ammer, Hermann   +5 more
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cortical kappa opioid receptors integrate negative affect and sleep disturbance

Translational Psychiatry
Sleep disruption and negative affect are attendant features of many psychiatric and neurological conditions that are often co-morbid including major depressive disorder, generalized anxiety disorder and chronic pain.
Robson C. Lillo Vizin, Hisakatsu Ito, Caroline M. Kopruszinski, Megumi Ikegami, Daigo Ikegami, Xu Yue, Edita Navratilova, Aubin Moutal, Stephen L. Cowen, Frank Porreca   +9 more
doaj   +1 more source

Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism

Addiction Neuroscience
Xylazine is in the unregulated drug supply at increasing rates, usually combined with fentanyl, necessitating understanding of its pharmacology. Despite commentary from politicians, and public health officials, it is unknown how xylazine impacts naloxone
Madigan L. Bedard, Xi-Ping Huang, Jackson G. Murray, Alexandra C. Nowlan, Sara Y. Conley, Sarah E. Mott, Samuel J. Loyack, Calista A. Cline, Caroline G. Clodfelter, Nabarun Dasgupta, Brian Krumm, Bryan L. Roth, Zoe A. McElligott   +12 more
doaj   +1 more source

Analgesic effects of deltorphin analogues EW1 and EW2 in tail-immersion test in mice

Current Issues in Pharmacy and Medical Sciences, 2013
The aim of the study was to evaluate whether EW1 and EW2, the newly synthesized analogues of deltorphin, a highly potent mu- (MOP) and delta-opioid receptors (DOP) ligand, induce antinociceptive effects in the tail-immersion test after ...
Ewa Gibuła-Bruzda, Marta Marszałek, Ewa Witkowska, Jolanta H. Kotlińska   +3 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Opioid Antagonists as a Potential Novel Class of Psychopharmacological Agents for Management of Anhedonia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева
The «anti-reward» system is closely linked to the functions of kappa-opioid (KOP) and nociceptin opioid (NOP) receptors. Their hyperactivation suppresses dopaminergic neurotransmission and leads to the development of anhedonia and negative affective ...
F. Sh. Shagiakhmetov, E. M. Krupitsky, I. Yu. Shamakina, P. K. Anokhin, M. L. Arkus, Yu. M. Scheidegger   +5 more
doaj   +1 more source