Results 41 to 50 of about 779,673 (234)

Kappa opioid receptor and oligodendrocyte remyelination

, 2019
Adult oligodendrocyte precursor cells (OPCs) maintain the abilities to differentiate and myelinate denuded axons in demyelinating diseases, such as Multiple Sclerosis (MS), albert often inefficiently. Remyelination therapies seek to enhance endogenous remyelination and represent a promising approach to achieve functional and cellular architectural ...
Fei Wang, Feng Mei
openaire   +3 more sources

Effectiveness of immersive virtual reality‐based interventions for alleviating peri‐ and post‐procedural pain and anxiety in gynecologic settings: A systematic review and meta‐analysis of randomized controlled trials

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Non‐pharmacological and complementary therapeutic, notably immersive virtual reality‐based interventions (IVR), could alleviate pain and anxiety associated with gynecologic procedures. Objective To evaluate the effectiveness of IVR in reducing peri‐ and post‐procedural pain and anxiety in gynecologic procedures.
Cristina González‐Lara, Marina Piñar‐Lara, Esteban Obrero‐Gaitán, Héctor García‐López, Irene Cortés‐Pérez   +4 more
wiley   +1 more source

Neurons derived from human-induced pluripotent stem cells express mu and kappa opioid receptors

Neural Regeneration Research, 2021
Neuroprotection studies have shown that induced pluripotent stem (iPS) cells have the possibility to transform neuroprotection research. In the present study, iPS cells were generated from human renal epithelial cells and were then differentiated into ...
Zhi-Hai Ju, Xuan Liang, Yao-Yao Ren, Luo-Wa Shu, Yan-Hong Yan, Xu Cui   +5 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

The Central Reinforcing Properties of Ethanol Are Mediated by Endogenous Opioid Systems: Effects of Mu and Kappa Opioid Antagonists.

Revista Argentina de Ciencias del Comportamiento, 2009
Endogenous opioid systems are implicated in the reinforcing effects of ethanol and may play a substantial role in modulating the central reinforcing effects of ethanol early in ontogeny.
Norman E. Spear, Elena I. Varlinskaya, Michael E Nizhnikov   +2 more
doaj  

Involvement of Peripheral Beta-Endorphin and MU, Delta, Kappa Opioid Receptors in Electro Acupuncture Analgesia for Prolonged Inflammatory Pain of Rats

European Journal of Inflammation, 2013
Acupuncture is commonly used to relieve chronic pain worldwide. Accumulating evidence shows that peripheral opioid system plays an important role in inhibiting inflammatory pain. This study aimed to investigate the involvement of peripheral opioid system
J.Q. Fang, Y.L. Jiang, S.C. Qiu, X.F. He, L. Huang, Y.F. Shen, X.H. Yin   +6 more
doaj   +1 more source

A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

Frontiers in Pharmacology, 2019
Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or ...
Kendall L. Mores, Benjamin R. Cummins, Robert J. Cassell, Robert J. Cassell, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +6 more
doaj   +1 more source

Effect of butorphanol in combination with xylazine during castration of calves: A randomised trial under field conditions

Veterinary Record, EarlyView.
Abstract Background In horses, cats and dogs, the opioid butorphanol has been proven effective in management of visceral pain and for peri‐ and postoperative pain relief. The aim of this study was to evaluate physiological responses and indicators of noxious stimuli when adding butorphanol to xylazine for sedation of bull calves during surgical ...
Axel Sannö, Lovisa Snygg, Maja Wiklund, Görel Nyman   +3 more
wiley   +1 more source

Benzodiazepine receptors and the control of ingestive behaviour in the rat [PDF]

, 1996
When administered systemically, benzodiazepine receptor agonists have been shown to increase food intake in a number of species. Conversely, benzodiazepine receptor inverse agonists bring about reliable decreases in feeding.
Higgs, Suzanne, Higgs, S
core