Results 21 to 30 of about 25,455 (216)
Scientific Reports, 2022 Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide (NFEPP)
Melih Ö. Celik +4 more
doaj +1 more source
Single high-dose buprenorphine for opioid craving during withdrawal. [PDF]
, 2018 BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a ...
Ahmadi, Jamshid +3 more
core +2 more sources
Frontiers in Pharmacology, 2023 Introduction: An active metabolite of buprenorphine (BUP), called norbuprenorphine (NorBUP), is implicated in neonatal opioid withdrawal syndrome when BUP is taken during pregnancy.
Venumadhav Janganati +10 more
doaj +1 more source
Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
core +2 more sources
Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor.
Justyna Piekielna-Ciesielska +7 more
doaj +1 more source
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Frontiers in Physiology, 2022 The opioid system in the brain is responsible for processing affective states such as pain, pleasure, and reward. It consists of three main receptors, mu- (μ-ORs), delta- (δ-ORs), and kappa- (κ-ORs), and their ligands – the endogenous opioid peptides ...
Utkarsha A. Singh, Soumya Iyengar
doaj +1 more source
Kappa receptor mediated opioid dependence in rhesus monkeys [PDF]
Life Sciences, 1986 The kappa receptor-selective agonist U-50, 488 was administered chronically to rhesus monkeys. Tolerance developed to the overt behavioral effects of U-50,488 without cross-tolerance to morphine. Withdrawal behaviors produced by deprivation, naloxone or quadazocine administration in U-50, 488-dependent monkeys consisted of hyperactivity, excessive ...
Gmerek, Debra E., Woods, James H.
openaire +3 more sources
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
core +1 more source
Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors [PDF]
, 2021 AbstractThe kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on the cellular level due to their therapeutic promise in retaining the analgesic and antipruritic effects and
Oberhauser, Lucie +1 more
openaire +3 more sources