Results 21 to 30 of about 83,214 (263)

Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain

Journal of Neuroscience, 2019
Pain is a multidimensional experience and negative affect, or how much the pain is “bothersome”, significantly impacts the sufferers' quality of life.
S. Liu, Sarah Pickens, Nicole E. Burma, I. Ibarra‐Lecue, Hongyan Yang, Lihua Xue, Christopher Cook, Joshua K. Hakimian, A. Severino, Lindsay M. Lueptow, Kristina Komarek, A. M. Taylor, M. Olmstead, F. Ivy Carroll, Caroline E. Bass, Anne M. Andrews, W. Walwyn, Tuan Trang, Christopher J. Evans, Frances M. Leslie, C. M. Cahill   +20 more
semanticscholar   +1 more source

Stress-induced reinstatement of nicotine preference requires dynorphin/kappa opioid activity in the basolateral amygdala [PDF]

, 2016
UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse.
Bruchas, Michael R, Carlezon, William A, Hourguettes, Nicholas J, Nygard, Stephanie K, Sobczak, Gabe G   +4 more
core   +2 more sources

Nalfurafine is Aversive at Antinociceptive Doses in Mice. [PDF]

Pharmacol Res Perspect
ABSTRACT Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood–brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atypical pharmacological profile.
Kuijer EJ, Marinelli LH, Bailey SJ, Heal DJ, Smith S, Wonnacott S, Bailey CP.   +6 more
europepmc   +2 more sources

Dynamic lateral organization of opioid receptors (kappa, muwt and muN40D) in the plasma membrane at the nanoscale level

Traffic : the International Journal of Intracellular Transport, 2018
Opioid receptors are important pharmacological targets for the management of numerous medical conditions (eg, severe pain), but they are also the gateway to the development of deleterious side effects (eg, opiate addiction).
Maciej K. Rogacki, Ottavia Golfetto, Steven J. Tobin, Tianyi Li, Sunetra Biswas, Raphael Jorand, Huiying Zhang, V. Radoi, Y. Ming, P. Svenningsson, Daniel Ganjali, D. Wakefield, Athanasios Sideris, A. Small, L. Terenius, T. Jovanović-Talisman, V. Vukojević   +16 more
semanticscholar   +1 more source

The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]

, 2015
The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA, MATTIA, Consalvo, Pergolizzi, Joseph, Raffa, Robert B   +3 more
core   +6 more sources

Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

Scientific Reports, 2022
Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide (NFEPP)
Melih Ö. Celik, Roger Negrete, Riccardo Di Rosso, Halina Machelska, Christoph Stein   +4 more
doaj   +1 more source

An opioid-like system regulating feeding behavior in C. elegans [PDF]

, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B., Avery, Leon, Cheong, Mi Cheong, You, Yong-Jai   +3 more
core   +3 more sources

Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens

International Journal of Neuropsychopharmacology, 2015
Background: Chronic ethanol exposure reduces dopamine transmission in the nucleus accumbens, which may contribute to the negative affective symptoms associated with ethanol withdrawal.
J. Rose, Anushree N. Karkhanis, Rong Chen, D. Gioia, Marcelo F. Lopez, H. Becker, B. McCool, S. Jones   +7 more
semanticscholar   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Journal of Medicinal Chemistry, 2015
Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors.
J. Cueva, Christopher Roche, M. Ostovar, Vinod Kumar, M. Clark, T. Hillhouse, J. Lewis, J. Traynor, S. Husbands   +8 more
semanticscholar   +1 more source