Results 221 to 230 of about 33,193 (249)

Biological activity of mu opioid receptor

Neuropharmacology, 1987
The purification of the mu-opioid receptor has proved to be more difficult than most other receptors for at least two reasons. First, they are easily inactivated by most detergents and the second problem is the heterogeneous existence of the opioid receptor.
S, Roy, H H, Loh
openaire   +2 more sources

Photoaffinity ligands for the MU opioid receptor

Life Sciences, 1993
Two affinity ligands, 6 beta-(5-Azido-2-nitrophenacetamido) 14 beta-hydroxy-7,8-dihydromorphinone (4) and 6 beta-(5-azido-2-nitrophenacetamido) 14 beta-hydroxy-7,8-dihydro-N- cyclopropylmethylnormorphinone (5) bind reversibly to opioid receptors present in bovine caudate membranes and photolyse in a range of wavelengths centered about 366 nm to produce
E J, Simon, L Q, Fan, J M, Hiller, A, Seyed-Mozaffari, A G, Schultz, S, Archer   +5 more
openaire   +2 more sources

Visualizing ligand bias at the Mu-opioid receptor

Cell, 2022
Different opioid ligands can result in biased μ-opioid signaling, differentially activating signal cascades which produce analgesia, tolerance, or adverse effects. In this issue of Cell, Xu et al. used cryo-EM and computational simulations to understand how different μ-opioid receptor selective-ligands interact with key residues to produce downstream ...
Catalina A, Zamorano, Michael R, Bruchas
openaire   +2 more sources

Targeting the mu-Opioid Receptor for Cancer Treatment

Current Oncology Reports, 2021
Opioids are still the most effective and widely used treatments for acute and chronic pain in cancer patients. This review focuses on the impact of opioids and mu-opioid receptors (MOR) on tumor progression and providing new ideas for targeting the MOR in cancer treatment.Studies estimated that opioids facilitate tumor progression and are related to ...
Hao, Zhang, Di, Zhou, Jiahui, Gu, Mengdi, Qu, Kefang, Guo, Wankun, Chen, Changhong, Miao   +6 more
openaire   +2 more sources

Mu-Opioid Receptor Expression in Laryngeal Cancer

Journal of Voice, 2023
Expression of mu-opioid receptors (MORs) has not been investigated in head and neck cancer. In this study, we aimed to assess the expression of opioids receptors in laryngeal cancer, compared to adjacent non-malignant tissue.A retrospective case series in a single academic center.Sixty-four specimens were taken from 32 matched patients, diagnosed with ...
Yonatan, Lahav, Oded, Cohen, Monica, Huszar, Iris, Levy, Juan P, Cata, Doron, Halperin, Hagit, Shoffel-Havakuk   +6 more
openaire   +2 more sources

Mu Opioid Receptor from the Zebrafish Exhibits Functional Characteristics as Those of Mammalian Mu Opioid Receptor

Zebrafish, 2009
The functional characterization of the mu opioid receptor from the zebrafish (zfMOR) is reported here. After transfection in HEK-293 cell line, using both peptidergic and nonpeptidergic opioid ligands in the competition and saturation-binding experiments, in addition to the functional assays of (35)S-GTPgammaS-binding assays and intracellular 3'-5 ...
Ezequiel, Marron Fdez de Velasco, Ping Y, Law, Raquel E, Rodríguez   +2 more
openaire   +2 more sources

Etonitazene: An opioid selective for the mu receptor types

Life Sciences, 1993
Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu 1, mu 2, delta, kappa 1 and sigma receptors. Both etonitazene and morphine displayed a mu 1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type.
M S, Moolten, J B, Fishman, J C, Chen, K R, Carlson   +3 more
openaire   +2 more sources