Results 21 to 30 of about 33,193 (249)
Frontiers in Behavioral Neuroscience, 2021 The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in ...
Sergey Sudakov, Natalia Bogdanova
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Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]
, 2017 Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun +2 more
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Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]
, 2006 Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M. +3 more
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Functional selectivity of EM-2 analogs at the mu-opioid receptor
Frontiers in Pharmacology, 2023 The mu opioid receptor agonists are the most efficacious pain controlling agents but their use is accompanied by severe side effects. More recent developments indicate that some ligands can differentially activate receptor downstream pathways, possibly ...
Justyna Piekielna-Ciesielska +6 more
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Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
Frontiers in Pharmacology, 2018 Mu opioid receptors modulate a large number of physiological functions. They are in particular involved in the control of pain perception and reward properties.
Muzeyyen Ugur +2 more
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Role of the mu-opioid receptor in opioid modulation of immune function [PDF]
Amino Acids, 2011 Endogenous opioids are synthesized in vivo to modulate pain mechanisms and inflammatory pathways. Endogenous and exogenous opioids mediate analgesia in response to painful stimuli by binding to opioid receptors on neuronal cells. However, wide distribution of opioid receptors on tissues and organ systems outside the CNS, such as the cells of the immune
Jana, Ninković, Sabita, Roy
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Mu and Delta Opioid Receptors Diverge [PDF]
Cell, 2009 Contrary to current models, Scherrer et al. (2009) provide evidence that mu and delta opioid receptors are not expressed by the same pain-sensing neurons. In mice, agonists for these receptors produce analgesia restricted to either noxious heat or mechanical stimuli, implying that the receptors act on distinct fibers to mediate completely different ...
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An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function [PDF]
The Scientific World JOURNAL, 2007 Morphine and related opiates are commonly used in the clinical management of various types of pain. However, the antinociceptive properties of morphine are often overshadowed by the development of tolerance and dependence following its chronic use. The mechanisms underlying opiate tolerance are not fully understood, but appear to involve numerous and ...
Raphael Rozenfeld +3 more
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Regulation of mu-opioid receptors by cytokines [PDF]
Frontiers in Bioscience, 2009 Opioids are the most potent analgesics. However, their clinical use is limited by side effects like respiratory depression and their high potential for abuse. In addition, they modulate immune functions and cause immunosuppression. Effects of clinically important opioids like morphine are mediated by the mu-opioid receptor.
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PLoS ONE, 2013 Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression.
Raphaël Weibel +9 more
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