Results 221 to 230 of about 729,259 (302)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Association of Depression and Anxiety With Postoperative Complications After Septoplasty With Turbinoplasty

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives Evaluate the association between comorbid depression and anxiety and postoperative complications following septoplasty with turbinoplasty, and assess whether treatment of these conditions influences surgical outcomes. Study Design Retrospective cohort study with propensity‐score matched analysis. Setting Multi‐institutional database
Amala Nayak, Iman Adibi, Suhas Rao Velichala, Michael F. Armstrong, Theodore Schuman   +4 more
wiley   +1 more source

Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats. [PDF]

Alcohol
Jennings MC, Sales Colquitt J, Carpenter BA, Hawks A, Ducceschi E, Lin M, Hays LS, Ferrario CR, Barson JR.   +8 more
europepmc   +1 more source

Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications

PM&R, EarlyView.
Abstract Background Hypovitaminosis D is associated with adverse health outcomes, including increased mortality in patients with cancer. Although vitamin D insufficiency (23%–72%) and deficiency (20%–71%) are common among patients admitted to inpatient rehabilitation, their prevalence and predictors in cancer‐specific inpatient rehabilitation ...
Jegy M. Tennison, Minxing Chen, Areeba Hafeez, Ananya Krishnan, Sefia Khan, Rony Dev, Sonal Admane, Eduardo Bruera   +7 more
wiley   +1 more source

Percutaneous peripheral nerve stimulation as an ancillary treatment following nerve repair surgery

PM&R, EarlyView.
Abstract Background Neuropathic pain after peripheral nerve injury severely degrades quality of life. Peripheral nerve stimulation (PN‐Stim) is cleared by the U.S, Food and Drug Administration for the treatment of acute and chronic pain. This broad indication supports its potential use at the time of peripheral nerve repair in patients reporting ...
Shyam Maisuria, Antonio Mondríguez‐González, Texakalidis Pavlos, Kevin N. Swong, Colin K. Franz   +4 more
wiley   +1 more source

Structural basis of opioid receptor activation by PCP and ketamine. [PDF]

Nat Struct Mol Biol
Jiang Q, Han J, Fine EJ, Ramos-Gonzalez N, Rangari VA, Ruiz MV, Critz ML, Suomivuori CM, Wang J, Albert TL, Whiddon K, Li K, Robertson MJ, Huang XP, Land BB, Majumdar S, Fay JF, Dror RO, Che T.   +18 more
europepmc   +1 more source

Transcriptional Reprogramming of GPCR Signaling Pathways in the Frontal Cortex of Morphine Dependent Mice. [PDF]

Biomol Ther (Seoul)
Kim M, Moon S, Yayeh T, Villa T, Oh S.
europepmc   +1 more source

Regulatory complaint patterns in physical medicine and rehabilitation: A population‐based cohort study

PM&R, EarlyView.
Abstract Background Regulatory complaints provide insight into physician performance and professionalism. Although complaint patterns have been described for the collective physician workforce, little is known about complaint risk among physical medicine and rehabilitation (PM&R) specialists (physiatrists).
Nigel Ashworth, Nicole Kain, Homeira Hamayeli‐Mehrabani, Kushagr Kumar, Nancy Hernandez‐Ceron, Iryna Hurava   +5 more
wiley   +1 more source

Sublingual Administration for Pain Control: Pharmacology, Clinical Applications and Future Directions. [PDF]

CNS Drugs
Koushik SS, Gritsenko K, Binda DD, Daybell IS, Hill NS, Raghavan J, Borukh E, Smith BB, Kraus M, Shaparin N.   +9 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source