Results 221 to 230 of about 117,188 (306)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Knowledge graph and emerging trends in β-arrestin research on pain: a bibliometric analysis (1997-2025). [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Yu H, Ding X, Zhang Y, Yu Y, Wang X.
europepmc   +1 more source

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

An emerging role for synaptic Zn²⁺ in substance use disorders. [PDF]

Pharmacol Ther
Solis O, Curry FP, Frangos ZJ, Dunne W, Schoenborn I, Lauer A, Gomez JL, Ventriglia EN, Bonaventura J, Michaelides M.   +9 more
europepmc   +1 more source

Parental Perspectives on Using the FLACC Scale for Postoperative Pain at Home After Orchiopexy

Pediatric Anesthesia, EarlyView.
Fie Juul Praastrup, Lone Nikolajsen, Camilla Gaarsdal Uhrbrand   +2 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Synthesis and evaluation of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors. [PDF]

RSC Med Chem
Ostovar M, Olsen K, Cami-Kobeci G, Traynor JR, Jeramaz L, Kirton SB, Husbands SM.   +6 more
europepmc   +1 more source

Universal Barriers and Facilitators to Systemic Hepatitis C Care: A Systems‐Informed Qualitative Process Evaluation

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Scaling up hepatitis C virus (HCV) testing and treatment for people who inject drugs (PWID) is essential to achieve HCV elimination. We report a retrospective systems‐informed qualitative process evaluation of HCV care across multiple community‐based settings in a region in Scotland, UK.
Gabriele Vojt, Lawrie Elliott, Hannah E. Family, Sharon J. Hutchinson, Matthew Hickman, John F. Dillon, Paul Flowers   +6 more
wiley   +1 more source

Preoperative caudal blocks associated with decreased cumulative opioid requirements compared to postoperative caudal blocks in pediatric urologic surgery

UroPrecision, EarlyView.
Abstract Background Caudal blocks (CB) are a cornerstone of pediatric urologic surgery, providing effective analgesia while mitigating potential neurotoxicity associated with general anesthesia and opioids. However, the optimal timing of CB—preoperative versus postoperative—remains controversial.
Jordan L. Mendelson, William Brenseke, Diego Alvarez Vega, William Nguyen, Mohammed Shium, Saige Gitlin, Ronnie G. Fine, Steven C. Friedman, Mark Horowitz, Walter I. Weiss, Raghu Idupuganti, Jordan S. Gitlin   +11 more
wiley   +1 more source