Results 251 to 260 of about 2,452,900 (288)

A photochromic agonist for μ-opioid receptors.

Angewandte Chemie, 2014
Opioid receptors (ORs) are widely distributed in the brain, the spinal cord, and the digestive tract and play an important role in nociception. All known ORs are G-protein-coupled receptors (GPCRs) of family A.
Matthias Schönberger, D. Trauner
semanticscholar   +1 more source

Opioids and Opioid Receptors in Peripheral Tissues

Scandinavian Journal of Gastroenterology, 1987
Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
Thomas Hedner, Jean Cassuto
openaire   +2 more sources

Opioids, opioid receptors, and the immune response

Drug and Alcohol Dependence, 2001
It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
Lois McCarthy, Judith K. Sliker, Toby K. Eisenstein, Thomas J. Rogers, Michele A. Wetzel   +4 more
openaire   +3 more sources

Regulation of Opioid Receptors by Their Endogenous Opioid Peptides

Cellular and Molecular Neurobiology, 2021
Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin.
Dinah L. Ramos-Ortolaza, Dinah L. Ramos-Ortolaza, Michael D. Hayward, Srinivas Gullapalli, Hui Pan, Hui Pan, Lakshmi A. Devi, Malcom J. Low, Malcom J. Low, Ivone Gomes, John E. Pintar, Achla Gupta   +11 more
openaire   +2 more sources

Opioid Peptides and their Receptors

1982
The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz, S.J. Paterson, L.E. Robson   +2 more
openaire   +3 more sources

Oligomerization of opioid receptors

Methods, 2002
Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP.
Julija Filipovska, Lakshmi A. Devi, Ivone Gomes, Bryen A. Jordan   +3 more
openaire   +3 more sources

Opioid Receptors and their Ligands

Current Topics in Medicinal Chemistry, 2004
This review gives a historical perspective, summarizing approximately 25 years of research on opioids. The "typical" opioid peptides produced in the brain, "atypical" opioids encrypted in milk protein or hemoglobin sequences, and extremely potent and selective opioids of amphibian origin are described.
Tomasz Janecki, Anna Janecka, Jakub Fichna   +2 more
openaire   +3 more sources

Receptors | Opioid Receptors

Encyclopedia of Biological Chemistry III, 2021
Hui Zheng, P. Law, H. H. Loh
semanticscholar   +1 more source

Opioid receptors and opioid pharmacodynamics

2005
Abstract Opioids have a long and rich pharmacology. They are widely used throughout medicine and have been invaluable. However, they come with problems, including side effects such as constipation, respiratory depression and sedation, as well as the potential of abuse.
Mellar P Davis, Gavril W Pasternak
openaire   +1 more source

ChemInform Abstract: Opioid‐Agonists and ‐Antagonists, Opioid‐Receptors

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T. Siener, Susanne Drosihn, Wolfgang Brandt, C. Nachtsheim, Ulrike Holzgrabe   +4 more
openaire   +3 more sources