Results 21 to 30 of about 729,259 (302)

Cocaine modulates the expression of opioid receptors and miR-let-7d in zebrafish embryos. [PDF]

PLoS ONE, 2012
Prenatal exposure to cocaine, in mammals, has been shown to interfere with the expression of opioid receptors, which can have repercussions in its activity.
Roger López-Bellido, Katherine Barreto-Valer, Fátima Macho Sánchez-Simón, Raquel E Rodríguez   +3 more
doaj   +1 more source

Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use

Addiction Neuroscience, 2023
Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
doaj   +1 more source

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

Frontiers in Immunology, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
doaj   +1 more source

Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression

Frontiers in Molecular Neuroscience, 2022
Impaired chemoreflex responses are a central feature of opioid-induced respiratory depression, however, the mechanism through which mu opioid receptor agonists lead to diminished chemoreflexes is not fully understood.
Sebastian N. Maletz, Brandon T. Reid, Adrienn G. Varga, Adrienn G. Varga, Erica S. Levitt, Erica S. Levitt   +5 more
doaj   +1 more source

Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective

Frontiers in Pharmacology, 2020
Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic ...
Li Zhang, Jiang-Tao Zhang, Lihua Hang, Tong Liu, Tong Liu   +4 more
doaj   +1 more source

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium [PDF]

, 2013
The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P., Carey, Michael F., Campion, Deirdre P., O\u27Connor, J. J., Fanning, Rebecca A., O'Connor, J. J., Carey, Michael F, Fanning, Rebecca A, Campion, Deirdre P, O'Connor, John J, McMorrow, Jason P   +10 more
core   +1 more source

Opioid receptors in GtoPdb v.2021.3 [PDF]

, 2021
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn),
Schulz, Stefan, Husbands, Stephen, Ueda, Hiroshi, Kieffer, Brigitte, Simon, Eric J., Toll, Lawrence, Civelli, Olivier, Meunier, Jean-Claude, Zaveri, Nurulain, Zimmer, Andreas, Henderson, Graeme, Borsodi, Anna, Caló, Girolamo, Christie, MacDonald J., Chavkin, Charles, Connor, Mark, Portoghese, Philip S., Bruchas, Michael, Kreek, Mary-Jeanne, Wong, Yung H., Kelly, Eamonn, Cox, Brian M., Kitchen, Ian, Traynor, John R., Massot, Dominique, Höllt, Volker, Liu-Chen, Lee-Yuan, Evans, Christopher, Shippenberg, Toni S., Devi, Lakshmi A., Nurulain Zaveri, Jean-Claude Meunier, John R. Traynor, Brigitte Kieffer, Philip S. Portoghese, Graeme Henderson, MacDonald J. Christie, Volker Höllt, Girolamo Caló, Lawrence Toll, Eamonn Kelly, Toni S. Shippenberg, Yung H. Wong, Eric J. Simon, Charles Chavkin, Lakshmi A. Devi, Michael Bruchas, Stephen Husbands, Christopher Evans, Dominique Massot, Stefan Schulz, Olivier Civelli, Lee-Yuan Liu-Chen, Ian Kitchen, Mary-Jeanne Kreek, Hiroshi Ueda, Andreas Zimmer, Mark Connor, Anna Borsodi, Brian M. Cox   +59 more
core   +1 more source

Co-Evolution of Opioid and Adrenergic Ligands and Receptors: Shared, Complementary Modules Explain Evolution of Functional Interactions and Suggest Novel Engineering Possibilities

Life, 2021
Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
doaj   +1 more source

Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]

, 2012
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas, Schwarz, Wolfgang, Xu, Nanjie, Pu, Lu, Pei, Gang, Gu, Quanbao, Xia, Peng, Ren, Shuanglai   +7 more
core   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria [PDF]

Advanced science
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Bouyssou A, Da Silva M, Soulé J, Fabre L, Lamarque L, Sounier R, Durroux T, Granier S, Roux T, Dupuis E, Trinquet E, Rondard P, Pin J.   +12 more
europepmc   +2 more sources