Results 141 to 150 of about 2,381,066 (350)

Age-Dependent Effects of Oxytocin and Oxytocin Receptor Antagonists on Bladder Contractions: Implications for the Treatment of Overactive Bladder Syndrome

Biomedicines
Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a profound impact on an individual’s quality of life.
Masroor Badshah, Jibriil Ibrahim, Nguok Su, Penny Whiley, Ralf Middendorff, Michael Whittaker, Betty Exintaris   +6 more
doaj   +1 more source

Low‐Field Magnetic Resonance Imaging of the Late Gestation Cervix and Birth Outcome Correlation: A Prospective Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To use low‐field MRI to produce reconstructions and 3D models of the cervix and to automate measurements for correlation with demographics and birth outcomes. Design Prospective cohort study. Setting KCL Advanced Imaging Centre, St Thomas's Hospital.
Simi Bansal, Alena U. Uus, Agnieszka Glazewska‐Hallin, Caitlin Allwin, Hadi Waheed, Vanessa Kyriakopoulou, Anna L. David, Dimitrios Siassakos, Manju Chandiramani, Jana Hutter, Lisa Story, Mary A. Rutherford   +11 more
wiley   +1 more source

Exogenous oxytocin administered to induce or augment labour is positively associated with quality of observed mother-infant bonding

Comprehensive Psychoneuroendocrinology
Oxytocin is a key hormone in the transition to motherhood. The maternal endogenous oxytocin system facilitates many physiological and biological adaptations, including breastfeeding, maternal wellbeing, and brain plasticity.
Hannah Edwards, Femke TA. Buisman-Pijlman, Adrian Esterman, Craig Phillips, Sandra Orgeig, Andrea Gordon   +5 more
doaj   +1 more source

Congenital CMV Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier, Valentine Faure Bardon, Leo Froelicher Bournaud, Isidore Gaubert, Tiffany Guilleminot, Marianne Leruez‐Ville, Jean‐Marc Treluyer, Yves Ville, Gabrielle Lui, Julien Stirnemann   +9 more
wiley   +1 more source

Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?

Pharmaceutics
Objective: Following a mild traumatic brain injury (mTBI), the most prevalent and profoundly debilitating occurrence is the emergence of an acute and persistent post-traumatic headache (PTH), for which there are presently no approved treatments.
Vimala N. Bharadwaj, Michael Klukinov, Robert Paul Cowan, Nazanin Mahinparvar, David John Clark, David Clifford Yeomans   +5 more
doaj   +1 more source

Oxytocin Increases Generosity in Humans [PDF]

Human beings routinely help strangers at costs to themselves. Sometimes the help offered is generous offering more than the other expects. The proximate mechanisms supporting generosity are not well-understood, but several lines of research suggest a ...
Ahmadi, Sheila, Stanton, Angela A., Zak, Paul J.   +2 more
core   +1 more source

Childhood Maltreatment and Cognitive Functioning in Bipolar Disorder: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Aims Characterising the association between childhood maltreatment (CM) and cognitive functioning in bipolar disorder (BD) is crucial for improving the understanding of how early environmental risk factors impact the presentation of the disorder.
Natalia E. Fares‐Otero, Anaid Pérez‐Ramos, Ricardo Lopez‐Escribano, Sara Martin‐Parra, Luis Alameda, Sarah L. Halligan, Kamilla Woznica Miskowiak, Eduard Vieta   +7 more
wiley   +1 more source

Muscarinic receptor blockade with oxybutynin reduces spontaneous and induced uterine muscle contractions

Pregnancy
Objective The uterus and the bladder have striking physiologic and anatomic similarities. Anticholinergic medications are commonly used to treat “overactive bladder” by targeting M2 and M3 muscarinic receptors.
Anthony G. Visco, Zachary R. Visco, Chad A. Grotegut, Cristina Linde, Timothy Westfall, Friederike L. Jayes   +5 more
doaj   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

The Multifaceted Role of Oxytocinergic System and OXTR Gene

Global Medical Genetics
The article explores the multifaceted role of the neuropeptide oxytocin in human behavior and its connection to the oxytocin receptor (OXTR) gene. Oxytocin, produced in specific brain nuclei, is implicated in emotional, social, and maternal behaviors ...
Rakibul Hasan
doaj   +1 more source