Results 161 to 170 of about 479 (208)
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1999
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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Oxytocin, oxytocin-associated neurophysin and the oxytocin receptor in the human prostate
Cell and Tissue Research, 2004Oxytocin has been implicated in the regulation of prostate growth. However, the cellular localisation of oxytocin in the normal and diseased human prostate is not known. Oxytocin, oxytocin-associated neurophysin and oxytocin receptor were detected by immunohistochemistry in tissues from patients undergoing routine prostatectomy and in normal human ...
Whittington, K +3 more
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A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Neuropharmacology, 2019Oxytocin mediates its behavioural effects via the centrally expressed oxytocin receptor (OTR). Oxytocin signalling has been implicated in multiple disorders involving centrally regulated pathways, including obesity, autism, schizophrenia and depression.
Shauna E. Wallace Fitzsimons +7 more
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Vasopressin and oxytocin receptors
Baillière's Clinical Endocrinology and Metabolism, 1996The oxytocin and the vasopressin V1a, V1b and V2 receptors have recently been cloned and shown to form a sub-family within the large superfamily of G-protein-linked receptors. Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.
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2008
The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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Oxytocin Receptor Antagonists: Update
Clinics in Perinatology, 1998For over three decades, scientists in a number of different laboratories have worked to design peptide analogues of oxytocin (OT) selective for the oxytocin receptor. Although there has been some interest in their use for treatment of dysmenorrhea, the principal clinical venue for such agents has been thought to lie in treatment of preterm labor.
T M, Goodwin, A, Zograbyan
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Oxytocin and Oxytocin Receptor Gene Expression in the Uterus
1995Publisher Summary The posterior pituitary contains a strong uterotonic activity known as the nonapeptide oxytocin (OT). It has been determined that uterus itself represents a major site of OT production. Therefore, the activation of uterine contractions by circulating OT is only one aspect of OT action. A significant portion of OT activity originates
H H, Zingg +6 more
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Oxytocin Receptors in Human Uterus*
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT [3H]oxytocin ([3H]OT) was bound in vitro to the 20,000 × g particulate fraction prepared from the myometrium of 2 women, 14–16 weeks pregnant. The apparent dissociation constants for oxytocin binding in preparations of the two uteri were 1.99 ± 0.18 (se) × 10−9 m (n = 9) and 2.81 ± 0.26 × 10−9 m (n = 10), respectively.
M S, Soloff, T L, Swartz, A H, Steinberg
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Oxytocin Antagonist (dTVT) and Oxytocin Receptors in Myometrium and Decidua
American Journal of Perinatology, 1989To investigate whether a putative oxytocin (OT) receptor blocker 1-deamino-[2-D-tyrosine (OEt)-4 threonine-8-ornithine]oxytocin (dTVT) inhibits OT binding to its receptors, we studied binding of [3H]OT to late-pregnant human, guinea pig, and rat myometrial and decidual membranes and competition of dTVT with this binding.
A R, Fuchs +3 more
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Molecular evolution of the oxytocin–oxytocin receptor system in eutherians
Molecular Phylogenetics and Evolution, 2013Oxytocin (OXT) is a nine-amino-acid peptide hormone that is mainly released at the times of uterine contractions during parturition and milk ejection during lactation, whereas a similar peptide hormone, arginine vasopressin, primarily exerts direct antidiuretic action on the kidney and causes vasoconstriction of the peripheral vessels. The genes coding
Kaoru, Yamashita, Takashi, Kitano
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