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A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Neuropharmacology, 2019Oxytocin mediates its behavioural effects via the centrally expressed oxytocin receptor (OTR). Oxytocin signalling has been implicated in multiple disorders involving centrally regulated pathways, including obesity, autism, schizophrenia and depression.
Shauna E. Wallace Fitzsimons +7 more
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2008
The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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1999
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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Vasopressin and oxytocin receptors
Baillière's Clinical Endocrinology and Metabolism, 1996The oxytocin and the vasopressin V1a, V1b and V2 receptors have recently been cloned and shown to form a sub-family within the large superfamily of G-protein-linked receptors. Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.
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Oxytocin and Oxytocin Receptors in Cancer Cells and Proliferation
Journal of Neuroendocrinology, 2004AbstractThe hypothalamic nonapeptide oxytocin plays a crucial role in many reproductive and behavioural functions. However, in recent years, an additional new role for oxytocin has been identified in neoplastic pathology. In tumours, oxytocin acts as a growth regulator, through the activation of a specific G‐coupled transmembrane receptor, the oxytocin
CASSONI, Paola +4 more
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Oxytocin Receptors in Human Uterus*
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT [3H]oxytocin ([3H]OT) was bound in vitro to the 20,000 × g particulate fraction prepared from the myometrium of 2 women, 14–16 weeks pregnant. The apparent dissociation constants for oxytocin binding in preparations of the two uteri were 1.99 ± 0.18 (se) × 10−9 m (n = 9) and 2.81 ± 0.26 × 10−9 m (n = 10), respectively.
M S, Soloff, T L, Swartz, A H, Steinberg
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Human osteoclasts express oxytocin receptor
Biochemical and Biophysical Research Communications, 2002Increasing evidences demonstrated many new targets for the hypothalamic hormone oxytocin, as the regulation of food balance and in some cases of leptin secretion. Considering that leptin is a potent inhibitor of bone formation and that oxytocin receptors (OTR) were detected in normal human osteoblasts, we investigated if OTR was expressed by human ...
COLUCCI, Silvia Concetta +4 more
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Oxytocin, oxytocin-associated neurophysin and the oxytocin receptor in the human prostate
Cell and Tissue Research, 2004Oxytocin has been implicated in the regulation of prostate growth. However, the cellular localisation of oxytocin in the normal and diseased human prostate is not known. Oxytocin, oxytocin-associated neurophysin and oxytocin receptor were detected by immunohistochemistry in tissues from patients undergoing routine prostatectomy and in normal human ...
Whittington, K +3 more
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Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour
Reproduction, 2000Oxytocin is used widely for the induction and augmentation of labour, but there is little information about the dynamics of oxytocin receptors in human myometrium during parturition, and the possible effect of oxytocin infusion. This information is important because G protein-coupled receptors, such as the oxytocin receptor, undergo desensitization ...
S, Phaneuf +4 more
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Oxytocin and Oxytocin Receptor Gene Expression in the Uterus
1995Publisher Summary The posterior pituitary contains a strong uterotonic activity known as the nonapeptide oxytocin (OT). It has been determined that uterus itself represents a major site of OT production. Therefore, the activation of uterine contractions by circulating OT is only one aspect of OT action. A significant portion of OT activity originates
H H, Zingg +6 more
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