Results 171 to 180 of about 39,424 (213)
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Oxytocin receptors in rat oviduct
Biochemical and Biophysical Research Communications, 1975The binding of tritiated oxytocin was studied in rat oviduct homogen ates sedimenting between 1000 X g for 10 minutes and 48000 X g for 30 minutes. Results showed that oxytocin is specifically bound to oviducal particles with high affinity. In particles prepared from estrogen-treated rats apparent Kd for oxytocin binding was 1.8 X 10 M.
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Oxytocin Antagonist (dTVT) and Oxytocin Receptors in Myometrium and Decidua
American Journal of Perinatology, 1989To investigate whether a putative oxytocin (OT) receptor blocker 1-deamino-[2-D-tyrosine (OEt)-4 threonine-8-ornithine]oxytocin (dTVT) inhibits OT binding to its receptors, we studied binding of [3H]OT to late-pregnant human, guinea pig, and rat myometrial and decidual membranes and competition of dTVT with this binding.
A R, Fuchs +3 more
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Molecular evolution of the oxytocin–oxytocin receptor system in eutherians
Molecular Phylogenetics and Evolution, 2013Oxytocin (OXT) is a nine-amino-acid peptide hormone that is mainly released at the times of uterine contractions during parturition and milk ejection during lactation, whereas a similar peptide hormone, arginine vasopressin, primarily exerts direct antidiuretic action on the kidney and causes vasoconstriction of the peripheral vessels. The genes coding
Kaoru, Yamashita, Takashi, Kitano
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Endogenous oxytocin inhibits morphine tolerance through limbic forebrain oxytocin receptors
Brain Research, 1988It has previously been shown that endogenous oxytocin (OXT) inhibits the development of acute morphine tolerance. The role of OXT receptors in the central nervous system (CNS) was therefore studied by using a specific OXT receptor antagonist, N-acetyl-(2-O-methyltyrosin)-OXT (ACME-OXT). ACME-OXT (1 pg) was injected into the posterior olfactory nucleus,
Z, Sarnyai +5 more
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Functional Architecture of Vasopressin/Oxytocin Receptors
Journal of Receptors and Signal Transduction, 1999Three-dimensional models of G protein-coupled receptors (GPCR) have been defined using most experimental data available and protein modeling techniques. The endogenous ligand binding sites have been qualitatively described and putative receptor activation mechanisms have been proposed.
M, Hibert +9 more
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Oxytocin Receptors and Neurobehavior
2016Research across species has shown that the neuropeptide oxytocin plays a key role in the regulation of social cognition and behavior. It is important for attachment, social exploration, and social recognition, as well as anxiety and stress-related behaviors. Based on oxytocin administration studies and measurements of peripheral oxytocin levels, it has
Robert Kumsta +2 more
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Oxytocin Receptors in Bovine Mammary Tissue
Journal of Receptor Research, 1987Oxytocin receptors were identified and characterized in bovine mammary tissue. [3H]-oxytocin was specifically bound to the 105,000 X g particulate fractions from 5 lactating cows and 5 non-lactating cows. Binding reached equilibrium by 50 min at 20 degrees C and by 8 hr at 4 degrees C.
X, Zhao, R C, Gorewit
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Receptors | Vasopressin/Oxytocin Receptor Family
2021Michael J. Brownstein, Vivian Kitainda
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Novel Nonpeptide as Oxytocin Receptor Agonist
ACS Medicinal Chemistry LettersThis highlight describes a series of novel 1,4-benzodiazepine-based nonpeptides as oxytocin receptor (OT) agonists. The reported compounds demonstrate enhanced potency and selectivity compared to reference compounds, warranting further investigation for potential therapeutic applications in the treatment of OT-related pathologies.
Yinlong Li, Steven H. Liang
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