Results 11 to 20 of about 479 (208)

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science
Until recently, it was widely assumed that oxytocin signaling occurred exclusively through the activation of neuronal oxytocin receptors, with neurons being the primary targets of released oxytocin.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
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An overview of the oxytocin-oxytocin receptor signaling network [PDF]

Journal of Cell Communication and Signaling, 2016
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment ...
Oishi, Chatterjee, Krutika, Patil, Apeksha, Sahu, Lathika, Gopalakrishnan, Praseeda, Mol, Jayshree, Advani, Srabani, Mukherjee, Rita, Christopher, T S Keshava, Prasad   +8 more
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Characterization and Expression of Oxytocin and the Oxytocin Receptor

Molecular Genetics and Metabolism, 2000
Oxytocin, a nonapeptide hormone and neurotransmitter, is expressed in a variety of tissues, as are its receptors. In vivo, oxytocin acts as a paracrine and/or autocrine mediator of multiple biological effects. These effects are exerted primarily through interactions with G-protein-coupled oxytocin/vasopressin receptors, which, via G(q) and G(i ...
H, Shojo, Y, Kaneko
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The Structure and Regulation of the Oxytocin Receptor [PDF]

Experimental Physiology, 2001
The oxytocin receptor (OTR) is part of an ancient hormone system expressed in diverse phyla in relation to acute reproductive smooth muscle responses, such as egg‐laying, birth, or milk letdown. The regulation of the OTR gene, while correlating with steroid levels in vivo, remains elusive.
Ivell, R., Kimura, T., Muller, D., Augustin, K., Abend, N., Bathgate, R., Telgmann, R., Balvers, M., Tillmann, G., Fuchs, A.   +9 more
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New Topics in Vasopressin Receptors and Approach to Novel Drugs: Vasopressin and Pain Perception

Journal of Pharmacological Sciences, 2009
Arginine vasopressin (AVP) activates three vasopressin receptors and it also has an agonistic activity on the oxytocin receptor. For an accurate description of the target receptor subtype(s) responsible for complex AVP and oxytocin actions, a careful ...
Taka-aki Koshimizu, Gozoh Tsujimoto
doaj   +1 more source

Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala

Biomedicines, 2021
Factors such as stress and anxiety often contribute to alcohol-dependent behavior and can trigger a relapse of alcohol addiction and use. Therefore, it is important to investigate potential pharmacological interventions that may alleviate the influence ...
Hannah S. Ballas, Samantha M. Wilfur, Nicole A. Freker, Kah-Chung Leong   +3 more
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The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human

BMC Gastroenterology, 2006
Background Oxytocin is released in response to a meal. Further, mRNA for oxytocin and its receptor have been found throughout the gastrointestinal (GI) tract.
Ekberg Olle, Björgell Ola, Ohlsson Bodil, Darwiche Gassan   +3 more
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Uterine receptor activation in response to uterotonic agents in late-pregnancy rat myometrium following pretreatment with oxytocin: an in vitro study

Clinical and Experimental Obstetrics & Gynecology, 2021
Background: Long term exposure to oxytocin reduces the ability of myometrium to respond to oxytocin, leading to oxytocin receptor (OXTR) desensitization.
Li-Mei Liao, Jian-Ying Hu, Ting-Ting Wang, Shao-Qiang Huang   +3 more
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Modern Views on the Neuropeptide Oxytocin. Part I. Oxytocin Structure, Synthesis, Excretion, Regulation, Inhibition and Metabolism. Oxytocin Receptors (Review)

Журнал медико-биологических исследований
It is known that the behavioural reactions of animals and humans are controlled by a number of neuropeptides. This article examines the modern views of scientists on the physiological effects of oxytocin and its influence on the social behaviour ...
Elena A. Leonova, Albina A. Bakhova, Irina L. Cherednik, Yulia V. Kashina, Aleksandr N. Ardelyan   +4 more
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Impact of magnesium on oxytocin receptor function

Pharmaceutics, 2022
Background and Purpose: The intranasal administration of oxytocin (OT) reduces migraine headaches through activation of the oxytocin receptor (OTR). Magnesium ion (Mg2+) concentration is critical to activation of OTR, and low serum Mg2+ concentration is predictive of migraine headache. We, therefore, examined the functional impact of Mg2+ concentration
Vimala N. Bharadwaj, Justin Meyerowitz, Bende Zou, Michael Klukinov, Ni Yan, Kaustubh Sharma, David J. Clark, Xinmin Xie, David C. Yeomans   +8 more
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