Results 1 to 10 of about 296,054 (292)

Expression and function of PDGF-C in development and stem cells

Open Biology, 2021
Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family, discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and platelet-derived growth factor B (PDGF-B).
Yi Tian, Ying Zhan, Qin Jiang, Weisi Lu, Xuri Li   +4 more
doaj   +1 more source

GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex

Biomolecules, 2023
Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie, Wenjing Tang, Shuang Wen, Fen Chen, Chao Yang, Min Wang, Yong Yang, Wei Liang   +7 more
doaj   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

Platelet-derived Growth Factors and Receptors in Canine Lymphoma [PDF]

Journal of Comparative Pathology, 2014
Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibitors in the treatment of several ...
ARICO', ARIANNA, GUADAGNIN, ELEONORA, FERRARESSO, SERENA, GELAIN, MARIA ELENA, Iussich S, Rütgen BC, MAZZARIOL, SANDRO, Marconato L, ARESU, LUCA   +8 more
openaire   +5 more sources

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]

Proceedings of the National Academy of Sciences, 2010
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after ...
P. Charles Lin, Xiaolin He, Xiaoyan Chen, Heli Liu, Ann Hye Ryong Shim, Pamela J. Focia   +5 more
openaire   +3 more sources

The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients. [PDF]

PLoS ONE, 2013
OBJECTIVES: The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing.
Jiing-Chyuan Luo, Yen-Ling Peng, Ming-Chih Hou, Kuang-Wei Huang, Hui-Chun Huang, Ying-Wen Wang, Han-Chieh Lin, Fa-Yauh Lee, Ching-Liang Lu   +8 more
doaj   +1 more source

VEGFR1-tyrosine kinase signaling in pulmonary fibrosis

Inflammation and Regeneration, 2021
Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono, Yoshiya Ito   +4 more
doaj   +1 more source

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Pulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu, Haiyang Tang, Ruizhu Lin, Shane G. Carr, Ziyi Wang, Aleksandra Babicheva, Ramon J. Ayon, Pritesh P. Jain, Mingmei Xiong, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Daniela Valdez-Jasso, Tatum S. Simonson, Ankit A. Desai, Joe G.N. Garcia, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.-J. Yuan   +21 more
doaj   +1 more source

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Dissociation of the ligand and dephosphorylation of the platelet‐derived growth factor receptor [PDF]

FEBS Letters, 1988
The ligand‐induced phosphorylation of the platelet‐derived growth factor (PDGF) receptor was followed at 37°C by a rapid dephosphorylation which was roughly parallel to the down regulation of the 125I‐PDGF binding sites. At 4°C, when the ligand‐receptor complexes remain associated with the cell surface, the phosphorylated form of the receptor was more ...
Sturani E, Zippel R, Morello L, Brambilla R, Alberghina L   +4 more
openaire   +4 more sources