Results 1 to 10 of about 347,631 (326)
Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis [PDF]
Journal of Internal Medicine, 2018 Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles during embryogenesis, particularly in the development of various mesenchymal cell types in different organs. In the adult, PDGF stimulates wound healing and regulates
C. Heldin +4 more
semanticscholar +4 more sources
Interactions between the receptors for platelet-derived growth factor and epidermal growth factor [PDF]
The Journal of cell biology, 1983 Preincubation of Swiss 3T3 cells or human fibroblasts with purified platelet-derived growth factor (PDGF) at 4 degrees C or 37 degrees C rapidly inhibits subsequent binding of 125I-epidermal growth factor (125I-EGF).
D. Bowen-Pope, P. Dicorleto, R. Ross
semanticscholar +4 more sources
Pharmaceuticals, 2010 Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF ...
Anca Maria Cimpean, Marius Raica
doaj +2 more sources
Expression and function of PDGF-C in development and stem cells
Open Biology, 2021 Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family, discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and platelet-derived growth factor B (PDGF-B).
Yi Tian +4 more
doaj +1 more source
GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex
Biomolecules, 2023 Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie +7 more
doaj +1 more source
Frontiers in Oncology, 2023 Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan +6 more
doaj +1 more source
Platelet-derived Growth Factors and Receptors in Canine Lymphoma [PDF]
Journal of Comparative Pathology, 2014 Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibitors in the treatment of several ...
ARICO', ARIANNA +8 more
openaire +5 more sources
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]
Proceedings of the National Academy of Sciences, 2010 Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after ...
P. Charles Lin +5 more
openaire +3 more sources
The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients. [PDF]
PLoS ONE, 2013 OBJECTIVES: The pathogenesis of the higher occurrence of peptic ulcer disease in cirrhotic patients is complex. Platelets can stimulate angiogenesis and promote gastric ulcer healing.
Jiing-Chyuan Luo +8 more
doaj +1 more source
VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
doaj +1 more source