Results 161 to 170 of about 444,848 (367)

Optimal experimental design in an EGFR signaling and down-regulation model [PDF]

arXiv, 2006
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv  

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Haematologica, 2019
There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating with the grade of myelofibrosis, knowledge on the precise role of PDGFRβ signaling in myelofibrosis ...
Kramer, Frederike, Dernedde, Jens, Mezheyeuski, Artur, Tauber, Rudolf, Micke, Patrick, Kappert, Kai   +5 more
openaire   +6 more sources

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, EarlyView.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion

BMC Cancer, 2011
Background E7080 is an orally active multi-targeted kinase inhibitor whose targets include vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptors (PDGFR).
Macleod Kenneth, Patel Hitesh, Mason Susan, Glen Hilary, Brunton Valerie G   +4 more
doaj   +1 more source

Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]

arXiv
During cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv  

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering

Advanced Materials Technologies, EarlyView.
Electrospinning enables the hierarchical assembly of nanofiber‐based scaffolds for tissue engineering. However, encapsulated proteins often undergo structural changes. This study used mesoporous silica nanoparticles (MSNs) as protective carriers, mitigating protein denaturation and supporting controlled release.
Vera Citro, Marta Clerici, Matthew T. Shephard, Tina P. Dale, Aldo R. Boccaccini, Nicholas R. Forsyth   +5 more
wiley   +1 more source

Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK

Haematologica, 2011
Background KANK1-PDGFRB is a fusion gene generated by the t(5;9) translocation between KANK1 and the platelet-derived growth factor receptor beta gene PDGFRB.
Sandrine Medves, Laura A. Noël, Carmen P. Montano-Almendras, Roxana I. Albu, Hélène Schoemans, Stefan N. Constantinescu, Jean-Baptiste Demoulin   +6 more
doaj   +1 more source

Stochastic Network Model of Receptor Cross-Talk Predicts Anti-Angiogenic Effects [PDF]

arXiv, 2008
Cancer invasion and metastasis depend on angiogenesis. The cellular processes (growth, migration, and apoptosis) that occur during angiogenesis are tightly regulated by signaling molecules. Thus, understanding how cells synthesize multiple biochemical signals initiated by key external stimuli can lead to the development of novel therapeutic strategies ...
arxiv  

The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation

Cardiology, 2016
<b><i>Objective:</i></b> To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived growth factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF). <b><i>Methods:</i></b> Thirty-nine AF patients and 33 patients with sinus rhythm (SR) were enrolled.
Zhiyuan Jiang, Lina Wen, Yujie Hong, Guirong Feng, Guoqiang Zhong, Peizhen Sun, Shuo Li, Shanshan Li, Shu Fang   +8 more
openaire   +2 more sources

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

Advanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana, Samartha M C, Ashwath Acharya, Goutam Thakur, Manasa Nune, Vipul Agarwal   +5 more
wiley   +1 more source