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Current Opinion in Nephrology and Hypertension, 2004
The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Christer, Betsholtz +5 more
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The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Christer, Betsholtz +5 more
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Receptors for Platelet-derived Growth Factor (PDGF)
1995Abstract The human a-receptor has 1089 amino acids including a 23-amino-acid leader sequence (GenBank accession number M22734 and M21574}, and the p-receptor has 1106 amino acids including a 32-amino-acid leader (GenBank accession number M21616 and JO3278) (Fig. 1).
C -H Heldin, L Claesson-Welsh
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Acta Haematologica, 2008
Rearrangements of the genes encoding the fibroblast growth factor receptor 1 (FGFR1) and platelet-derived growth factor receptors (PDGFR) α or β receptor tyrosine kinases are found in a rare but important subset of patients with atypical myeloproliferative disorders that are usually but not always associated with eosinophilia.
Cross, N.C., Reiter, A.
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Rearrangements of the genes encoding the fibroblast growth factor receptor 1 (FGFR1) and platelet-derived growth factor receptors (PDGFR) α or β receptor tyrosine kinases are found in a rare but important subset of patients with atypical myeloproliferative disorders that are usually but not always associated with eosinophilia.
Cross, N.C., Reiter, A.
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Platelet-Derived Growth Factor B Type Receptor
1990Platelet-derived growth factor (PDGF) is a major mitogen in serum for connective tissue cells (for reviews, see Heldin et al., 1985; Ross et al., 1986). The in vivo function of PDGF is not known. However, the fact that PDGF is released from platelets in conjunction with the blood coagulation and stimulates not only proliferation, but also chemotaxis ...
Carl-Henrik Heldin, Lars Rönnstrand
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Signal Transduction by the Platelet-Derived Growth Factor Receptor
Science, 1989When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a remarkably diverse group of biochemical responses, including changes in ion fluxes, activation of several kinases, alterations in cell shape, increased transcription of a number of genes, and stimulation of enzymes that ...
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The Platelet-Derived Growth Factor Receptor
International Journal of Neuroscience, 1985D F, Bowen-Pope +3 more
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Receptors | Platelet-Derived Growth Factor Receptor Family
2021Marina V. Kovalenko +2 more
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Receptors for platelet-derived growth factor on microvascular endothelial cells
1992Endothelial cells are widely thought to be unresponsive to platelet-derived growth factor (PDGF) and devoid of PDGF receptors. However, in examining the growth factor responses of microvascular endothelial cells isolated from human omental adipose tissue, we detected PDGF-induced tyrosine phosphorylation of an 180-kD glycoprotein, subsequently ...
J G, Beitz +3 more
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The platelet-derived growth factor receptor as a therapeutic target
Current Oncology Reports, 2007Several small molecule tyrosine kinase inhibitors that block the epidermal growth factor receptor and vascular endothelial growth factor receptor function are among the many recently developed targeted anticancer therapeutic agents. Increasing evidence indicates that inhibition of other tumor stromal targets could provide additional and possibly ...
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