Results 31 to 40 of about 444,848 (367)

Negative regulation of receptor tyrosine kinases by ubiquitination: Key roles of the Cbl family of E3 ubiquitin ligases

Frontiers in Endocrinology, 2022
Receptor tyrosine kinases (RTKs) serve as transmembrane receptors that participate in a broad spectrum of cellular processes including cellular growth, motility, differentiation, proliferation, and metabolism. Hence, elucidating the regulatory mechanisms
Rong Tang, Wallace Y. Langdon, Jian Zhang   +2 more
doaj   +1 more source

Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling

Nature Network Boston, 2018
Breast tumors of the basal-like, hormone receptor–negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment.
Pernilla Roswall, M. Bocci, M. Bartoschek, Hong Li, G. Kristiansen, S. Jansson, S. Lehn, Jonas Sjölund, Steven Reid, C. Larsson, P. Eriksson, Charlotte Anderberg, E. Cortez, L. Saal, Christina Orsmark-Pietras, E. Cordero, B. K. Haller, J. Häkkinen, I. Burvenich, E. Lim, A. Orimo, M. Höglund, L. Rydén, H. Moch, A. Scott, U. Eriksson, K. Pietras   +26 more
semanticscholar   +1 more source

Targeting VEGF-VEGFR Pathway by Sunitinib in Peripheral Primitive Neuroectodermal Tumor, Paraganglioma and Epithelioid Hemangioendothelioma: Three Case Reports

Case Reports in Oncology, 2013
Sunitinib malate (Sutent™; Pfizer Inc., New York, N.Y., USA) is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including vascular endothelial growth factor receptors, stem-cell factor receptor, and platelet-
Tiziana Prochilo, Giordano Savelli, Paola Bertocchi, Chiara Abeni, Luigina Rota, Anna Rizzi, Alberto Zaniboni   +6 more
doaj   +1 more source

A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]

Advances in Virology Volume 2011 (2011), Article ID 262080, 11 pages, 2010
Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved. Here, by employing systems biology approach, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic ...
arxiv   +1 more source

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

Journal of Biological Chemistry, 1982
Two homobifunctional cross-linking reagents have been used to cross-link 125I-platelet-derived growth factor (PDGF) to a cell surface component with an approximate Mr = 164,000 that has many characteristics of a specific PDGF receptor. Excess unlabeled PDGF competed for labeling of this component, while high concentrations of fibroblast growth factor ...
K Glenn, D F Bowen-Pope, Russell Ross
openaire   +3 more sources

Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

Cold Spring Harbor Perspectives in Biology, 2013
The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors, which are characterized by five Ig-like domains extracellularly and a split kinase domain intracellularly.
C. Heldin, J. Lennartsson
semanticscholar   +1 more source

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]

Arthritis Research \& Therapy, 2010, 13 (1), pp.R23. \. \<10.1038/sj.onc.1204808\>, 2015
Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv   +1 more source

Platelet-derived growth factors and their receptors: Structural and functional perspectives [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important functions in the development of connective tissue cells. Recent structural studies have revealed novel mechanisms of PDGFs in propeptide loading and receptor recognition/activation ...
Xiaolin He, Xiaoyan Chen, Po Han Chen
openaire   +3 more sources

Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

Respiratory Research, 2017
Background Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for ...
Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara, Yasuhiko Nishioka   +15 more
doaj   +1 more source