Platelet-derived growth factor receptor-β in Gorham's disease [PDF]
Nature Clinical Practice Oncology, 2006 A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass
Jeroen, Hagendoorn +11 more
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PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. [PDF]
, 2014 Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often ...
Abbott, Nicholas +11 more
core +2 more sources
Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
Respiratory Research, 2017 Background Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for ...
Seidai Sato +15 more
doaj +1 more source
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [PDF]
PLoS ONE, 2012 Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies.
Stephen R Spindler +4 more
doaj +1 more source
PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells
PLoS ONE, 2022 Mechanically stressed vascular smooth muscle cells (VSMCs) have potential roles in the development of vascular complications. However, the underlying mechanisms are unclear.
Ji On Kim +5 more
doaj +2 more sources
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]
, 2019 We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina +9 more
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Vascular endothelial growth factor can signal through platelet-derived growth factor receptors [PDF]
The Journal of Cell Biology, 2007 Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and ...
Ball, Stephen G. +2 more
openaire +3 more sources
Growth Factors in Human Ovarian Follicle Fluid and Growth Factor Receptors in Granulosa-Luteal Cells
The International Journal of Biological Markers, 1995 The levels of oestradiol (E 2 ), progesterone (P 4 ), transforming growth factor a (TGFa), transforming growth factor β2 (TGFβ 2 ), insulin-like growth factor I (IGF-I), platelet-derived growth factor AB (PDGF-AB) and epidermal growth factor (EGF) were ...
R. McWilliam, R.E. Leake, J.R.T. Coutts
doaj +1 more source
Hypoxic Ventilatory Response in Platelet-Derived Growth Factor Receptor-β–Knockout Mice
Journal of Pharmacological Sciences, 2009 .: The present study investigated whether the platelet-derived growth factor receptor (PDGFR)-β–mediated mechanisms are involved in the hypoxic ventilatory response through modulating the N-methyl-D-aspartate (NMDA) function.
Saori Tsunekawa +4 more
doaj +1 more source
Platelet-Derived Growth Factor Receptor-β Expression in Human Peritoneum [PDF]
Nephron Clinical Practice, 2014 <b><i>Introduction:</i></b> Simple peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS) are important lesions in the peritoneum of patients on peritoneal dialysis (PD). We have previously described a population of podoplanin-positive myofibroblasts in peritoneal biopsies from patients with EPS.
Harald Seeger +9 more
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