Results 41 to 50 of about 444,848 (367)

Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [PDF]

PLoS ONE, 2012
Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies.
Stephen R Spindler, Rui Li, Joseph M Dhahbi, Amy Yamakawa, Frank Sauer   +4 more
doaj   +1 more source

Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.

Genes & Development, 2012
Growth factor-mediated proliferation and self-renewal maintain tissue-specific stem cells and are frequently dysregulated in cancers. Platelet-derived growth factor (PDGF) ligands and receptors (PDGFRs) are commonly overexpressed in gliomas and initiate ...
Youngmi Kim, Eunhee Kim, Qiulian Wu, O. Guryanova, M. Hitomi, J. Lathia, David R. Serwanski, A. Sloan, R. Weil, Jeongwu Lee, A. Nishiyama, S. Bao, A. Hjelmeland, J. Rich   +13 more
semanticscholar   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

Proceedings of the National Academy of Sciences of the United States of America, 1981
A cellular receptor for platelet-derived growth factor (PDGF) was demonstrated by incubation of 125I-labeled PDGF with human foreskin fibroblast cultures followed by liberation of cell-bound radioactivity with Triton X-100.
C. Heldin, B. Westermark, Å. Wasteson
semanticscholar   +1 more source

Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity [PDF]

, 2021
Background: Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for
Abe, Shuichi, Aono, Yoshinori, Chen, Yanjuan, Goto, Hisatsugu, Hayashi, Shinya, Kawano, Hiroshi, Koyama, Kazuya, Morizumi, Shun, Nishimura, Haruka, Nishioka, Yasuhiko, Ogawa, Hirohisa, Okazaki, Hiroyasu, Sato, Seidai, Shinohara, Shintaro, Toyoda, Yuko, Uehara, Hisanori   +15 more
core  

Molecular docking study of new sorafenib analogues as platelet-derived growth factor receptor inhibitors for the treatment of cancer

Journal of Pharmacy and Bioallied Sciences, 2023
Cancer is a disease triggered by an uncontrolled growth of a group of cells usually from a single cell. Chemotherapy is a common and systematic therapy that involves the use of anticancer drugs also known as chemotherapeutical agents to treat cancer ...
Marwan I Jihad, Monther F Mahdi
doaj   +1 more source

Platelet-derived growth factor receptor-β in Gorham's disease [PDF]

Nature Clinical Practice Oncology, 2006
A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass
Andrew E. Rosenberg, Dan G. Duda, Thomas F. DeLaney, Rakesh K. Jain, David H. Ebb, Henning A. Gaissert, G. Petur Nielsen, Jennifer M. Pearce, Torunn I. Yock, Timothy P. Padera, Jeroen Hagendoorn, Emmanuelle di Tomaso   +11 more
openaire   +3 more sources

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

Cancer Research, 2006
The growth of solid tumors is dependent on the continued stimulation of endothelial cell proliferation and migration resulting in angiogenesis. The angiogenic process is controlled by a variety of factors of which the vascular endothelial growth factor ...
A. Polverino, A. Coxon, C. Starnes, Zobedia Diaz, T. DeMelfi, Ling Wang, J. Bready, Juan Estrada, R. Cattley, S. Kaufman, Danlin Chen, Yongmei Gan, Gondi N. Kumar, James T. Meyer, Sesha Neervannan, Gonzalo Alva, J. Talvenheimo, S. Montestruque, A. Tasker, V. Patel, R. Radinsky, R. Kendall   +21 more
semanticscholar   +1 more source

Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

Kidney Diseases, 2020
Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they
Liu Feng, Wang Li, Yu Chao, Qin Huan, Fang Lu, Wang Yi, Wang Jun, Cui Binbin, Liu Na, Zhuang Shougang   +9 more
doaj   +1 more source

The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. [PDF]

PLoS ONE, 2013
BACKGROUND:Pulmonary hypertension (PH) is a progressive disorder characterized by an increase in pulmonary artery pressure and structural changes in the pulmonary vasculature.
Mohamed Izikki, Olaf Mercier, Florence Lecerf, Lauriane Lubert Guin, Eric Hoang, Peter Dorfmüller, Frédéric Perros, Marc Humbert, Gerald Simonneau, Philippe Dartevelle, Elie Fadel, Saadia Eddahibi   +11 more
doaj   +1 more source