Results 41 to 50 of about 192,054 (308)

Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

Kidney Diseases, 2020
Background: Our recent studies demonstrated that both nintedanib, an FDA-approved quadruple kinase inhibitor, and gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, protect against obstructive kidney disease. It remains unknown whether they
Liu Feng, Wang Li, Yu Chao, Qin Huan, Fang Lu, Wang Yi, Wang Jun, Cui Binbin, Liu Na, Zhuang Shougang   +9 more
doaj   +1 more source

The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. [PDF]

PLoS ONE, 2013
BACKGROUND:Pulmonary hypertension (PH) is a progressive disorder characterized by an increase in pulmonary artery pressure and structural changes in the pulmonary vasculature.
Mohamed Izikki, Olaf Mercier, Florence Lecerf, Lauriane Lubert Guin, Eric Hoang, Peter Dorfmüller, Frédéric Perros, Marc Humbert, Gerald Simonneau, Philippe Dartevelle, Elie Fadel, Saadia Eddahibi   +11 more
doaj   +1 more source

Molecular docking study of new sorafenib analogues as platelet-derived growth factor receptor inhibitors for the treatment of cancer

Journal of Pharmacy and Bioallied Sciences, 2023
Cancer is a disease triggered by an uncontrolled growth of a group of cells usually from a single cell. Chemotherapy is a common and systematic therapy that involves the use of anticancer drugs also known as chemotherapeutical agents to treat cancer ...
Marwan I Jihad, Monther F Mahdi
doaj   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Akl EA, Alpa M. Nick, Angela F. Drew, Anil K. Sood, Bulent Ozpolat, Chad V. Pecot, Charles N. Landen, Diana Urbauer, Donald Lamkin, Edward H. Ahn, Erin R. King, Frances Balkwill, Francisca Gushiken, Gabriel Lopez-Berestein, Guillermo N. Armaiz-Pena, Hannah Gershenson, Hee Dong Han, Hernan G. Vasquez, Iain A. McNeish, Ibrahim Tekedereli, Jermaine Coward, Justin Bottsford-Miller, Katherine Collins, Koen DeGeest, Koji Matsuo, Mian M.K. Shahzad, Michael T. Deavers, Rajesha Rupaimoole, Rebecca L. Stone, Riess L, Rui Wang, Susan K. Lutgendorf, Vahid Afshar-Kharghan, Virginia K. Bond, Wah Chiu, Wei Hu   +35 more
core   +1 more source

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy

Pharmaceuticals, 2010
Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF ...
Anca Maria Cimpean, Marius Raica
doaj   +1 more source

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. [PDF]

PLoS ONE, 2015
Hydrogen peroxide-inducible clone-5 (Hic-5) is a transforming growth factor (TGF)-β1-inducible focal adhesion protein. We previously demonstrated that Hic-5 was localized in mesangial cells and its expression was associated with glomerular cell ...
Ariunbold Jamba, Shuji Kondo, Maki Urushihara, Takashi Nagai, Joo-Ri Kim-Kaneyama, Akira Miyazaki, Shoji Kagami   +6 more
doaj   +1 more source

Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: A proof-of-concept study in the preoperative window period (ImPACCT) [PDF]

, 2017
Background: The identification of four Consensus Molecular Subtypes (CMS1-4) of colorectal cancer forms a new paradigm for the design and evaluation of subtype-directed therapeutic strategies.
Bloemendal, H.J. (Haiko), Boerman, A.W., Borel Rinkes, I.H.M. (Inne), Brink, M.A. (Menno), Elias, S.G. (Sjoerd), Grevenstein, H.M.U. (Helma) van, Holierhoek, Y.C.W., Koopman, M. (Miriam), Kranenburg, O. (Onno), Leng, W.W.J. (Wendy) de, Lolkema, M.P. (Martijn), Mathijssen, A.H.J. (Ron), Schwartz, M.P. (Matthijs), Ubink, I., Verheijen, P.M., Weger, R.A. (Roel) de   +15 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Small Molecule Tyrosine Kinase Inhibitor Nintedanib Reduces Development of Cardiac Allograft Vasculopathy in Murine Aortic Allografts

Transplantation Direct, 2018
Background. Nintedanib is a small molecule tyrosine kinase inhibitor that blocks the action of the platelet-derived growth factor receptor (PDGFR), the vascular endothelial growth factor receptor (VEGFR) and the fibroblast growth factor receptor.
Annika Gocht, Bernd Spriewald, MD, DPhil, Jörg H.W. Distler, MD, Martina Ramsperger-Gleixner, PhD, Stephan M. Ensminger, MD, DPhil, Michael Weyand, MD, Christian Heim, MD   +6 more
doaj   +1 more source