Results 51 to 60 of about 444,848 (367)

Platelet-derived growth factor receptors and phospholipase C activation

Kidney International, 1992
Platelet-derived growth factor (PDGF) has been assigned a broad range of biological roles in contexts ranging from development and oncogenesis to wound healing and atherogenesis [1]. Originally assayed as mitogenic activity released from platelets, it is now appreciated that, in addition to its proliferative actions, PDGF stimulates other processes ...
Thomas O. Daniel, Dana A. Kumjian
openaire   +3 more sources

Activation of multiple growth factor signalling pathways is frequent in meningiomas [PDF]

, 2015
A minority of meningiomas are difficult to treat with surgery or radiotherapy, and chemotherapeutic alternatives are limited. This study aims to better understand pathways that are active in meningiomas, in order to direct future treatment strategies. We
Bassiri, K, Enki, DG, Hanemann, CO, Hilton, DA, Kirk, L, Shivane, A   +5 more
core   +2 more sources

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

Journal of Clinical Investigation, 1989
Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type.
S. Friedman, M. Arthur
semanticscholar   +1 more source

Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics [PDF]

Biophysical Journal 76, 188 (1999), 1999
Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational changes in the protein which induce transactivation or transrepression of the target genes.
arxiv   +1 more source

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

Journal of Biological Chemistry, 2001
Here we provide evidence to show that the platelet-derived growth factor beta receptor is tethered to endogenous G-protein-coupled receptor(s) in human embryonic kidney 293 cells.
Forbes Alderton, S. Rakhit, K. Kong, T. Palmer, B. Sambi, S. Pyne, N. Pyne   +6 more
semanticscholar   +1 more source

Identification and super-resolution imaging of ligand-activated receptor dimers in live cells [PDF]

Scientific Reports 3 (2013) 2387, 2013
Molecular interactions are key to many chemical and biological processes like protein function. In many signaling processes they occur in sub-cellular areas displaying nanoscale organizations and involving molecular assemblies. The nanometric dimensions and the dynamic nature of the interactions make their investigations complex in live cells.
arxiv   +1 more source

Magnetic Iron Nanocubes Effectively Capture Epithelial and Mesenchymal Cancer Cells [PDF]

ACS Omega 2020, 5, 37, 23724 23735, 2020
Current methods for capturing circulating tumor cells (CTCs) are based on the overexpression of cytokeratin (CK) or epithelial cell-adhesion molecule (EpCAM) on cancer cells. However, during the process of metastasis, tumor cells undergo epithelial to mesenchymal transition (EMT) that can lead to the loss of CK/EpCAM expression.
arxiv   +1 more source

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

Proceedings of the National Academy of Sciences of the United States of America, 1984
A series of nontransformed human and murine cells and derivative cell lines transformed by methylcholanthrene; by simian virus 40, Kirsten and Moloney murine sarcoma viruses, simian sarcoma virus, and adenovirus; and by a "spontaneous" event in culture ...
D. Bowen-Pope, A. Vogel, R. Ross
semanticscholar   +1 more source

A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment [PDF]

, 2015
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1 through 3 (VEGFR1-VEGFR3), fibroblast growth factor receptors 1 through 4 (FGFR1-FGFR4), platelet-derived growth factor receptor α ...
Allison, Roger, Andresen, Corina, Ball, Douglas W., Bodenner, Donald L, Cabanillas, Maria E, Elisei, Rossella, Funahashi, Yasuhiro, Jarzab, Barbara, Licitra, Lisa F, Martins, Renato G, Mccaffrey, Judith C, Newbold, Kate, O'Brien, James P, PACINI, FURIO, Ren, Min, Robinson, Bruce, Schlumberger, Martin, Shah, Manisha H, Sherman, Steven I, Topliss, Duncan   +19 more
core   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source