Results 11 to 20 of about 152,856 (310)

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells [PDF]

, 1993
Luteal cells are known to possess receptors for LH/hCG and receptors of the beta-adrenergic type. Interactions of specific agonists with either receptor lead to the activation of adenylate cyclase and subsequently to an increase of cAMP.
Föhr, K. J., Gratzl, Manfred, Mayerhofer, Artur, Rosenbusch, B., Rudolf, M., Sterzik, K.   +5 more
core   +1 more source

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source

A novel therapeutic approach for treatment of catamenial epilepsy

Neurobiology of Disease, 2018
Many women with epilepsy experience perimenstrual seizure exacerbation, referred to as catamenial epilepsy. There is no effective treatment for this condition, proposed to result from withdrawal of neurosteroid-mediated effects of progesterone.
Suchitra Joshi, Huayu Sun, Karthik Rajasekaran, John Williamson, Edward Perez-Reyes, Jaideep Kapur   +5 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2011 Spandidos Publications Ltd.A vital function of the human placenta is to produce steroid hormones such as ...
Foster, H, Goumenou, A, Karteris, E, Rand-Weaver, M, Thomas, P, Zachariades, E   +5 more
core   +1 more source

Progesterone Regulation of the Progesterone Receptor in Rat Gonadotropes* [PDF]

Endocrinology, 2000
For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms.
J L, Turgeon, D W, Waring
openaire   +2 more sources

Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra

Acta Veterinaria, 2018
The estrus cycle of bitches is divided into four phases: proestrus, estrus, diestrus and anestrus, during which different morphological changes, and also cyclic changes of estrogen and progesterone receptors are present.
Marinković Darko, Aničić Milan, Vakanjac Slobodanka, Nedić Svetlana, Magaš Vladimir   +4 more
doaj   +1 more source

Progesterone signaling mechanisms in brain and behavior

Frontiers in Endocrinology, 2012
Steroid hormone, progesterone, modulates neuroendocrine functions in the central nervous system resulting in alterations in physiology and behavior.
Shaila eMani, Mario G Oyola
doaj   +1 more source