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Activation of Progesterone Receptor by ATP

European Journal of Biochemistry, 1981
Progesterone-receptor complex from freshly prepared hen oviduct cytosol acquired the ability to bind to isolated nuclei, DNA-cellulose and ATP-Sepharose when incubated with 5-10 mM ATP at 4 degrees C. The extent of this ATP-dependent activation was higher when compared with heat-activation achieved by warming the progesterone-receptor complex at 23 ...
V, Moudgil   +5 more
openaire   +2 more sources

Progesterone Receptors in Rat Thymus

Endocrinology, 1983
Tritiated promegestone ([3H]R5020) is bound with high affinity in cytosol prepared from the thymus gland of both male and female rats. To prevent tracer binding to glucocorticoid receptors, we have used excess RU26988 (11 beta, 17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one), a highly specific synthetic glucocorticoid.
P T, Pearce, B A, Khalid, J W, Funder
openaire   +2 more sources

Progesterone and the progesterone receptor.

The Journal of reproductive medicine, 2001
During the 1990s, extensive research has effectively mapped the progesterone receptor-mediated actions of progesterone and has more recently uncovered nonreceptor-mediated effects--the effect of progesterone on uterine sensitivity to oxytocin, for example, involves direct, nongenomic progesterone action on the uterine oxytocin receptor.
openaire   +1 more source

PROGESTERONE RECEPTORS IN BREAST CANCER

Australian and New Zealand Journal of Surgery, 1984
Sixty‐six women who had received hormonal therapy for advanced disease were assessed for objective response to treatment. Another 51 patients who had received chemotherapy were similarly studied. Progesterone receptor was of no value as a predictor of patients unlikely to respond to hormone therapy, though it may have a role in predicting patients ...
R M, Bryan   +5 more
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Estrogen and progesterone receptors in meningiomas

Surgical Neurology, 1986
Estradiol and progesterone receptors were studied in 14 patients with meningiomas. Estrogen receptors were detected by specific monoclonal antibodies, whereas progesterone receptors were assayed by the dextran-coated charcoal method. In 9 cases the estrogen receptors were also investigated in cultured tumor cells.
MAIURI, FRANCESCO   +2 more
openaire   +3 more sources

Progesterone Receptor in Cystosarcoma Phyllodes

Archives of Surgery, 1977
A specific receptor for progesterone has been found in a cystosarcoma phyllodes, as determined by charcoal adsorption and sucrose gradient analysis. Similar assays for estrogen receptors were negative. The tumor consisted almost entirely of stroma that contained the progesterone receptors.
B R, Rao, J S, Meyer
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UTERINE PROGESTERONE AFTER PROGESTERONE TREATMENT: ON THE DISAPPEARANCE OF CYTOSOLIC PROGESTERONE RECEPTORS

Journal of Steroid Biochemistry, 1979
Abstract The effect of progesterone (P) treatment on P receptors and on the resultant P concentrations in the cytoplasm and other subcellular fractions was studied. Cytoplasmic P receptors in the uterus of oestrogenized rabbits were reduced by about 60% after 24 h of single injection of P.
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Progesterone Receptor Interaction with Chromatin

2014
Understanding how eukaryotic gene regulation works implies unraveling the mechanisms used by transcription factors to access DNA information packaged in chromatin. The current view is that different cell types express different parts of the genome because they are equipped with different sets of transcription factors.
Guillermo P, Vicent   +5 more
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Progesterone Receptors of Chick Oviduct

1978
The chick oviduct progesterone receptor has been purified to homogeneity by affinity chromatography and its molecular action studied in vitro. The native receptor is a 200,000 MW dimer of two dissimilar 4S subunits with different intranuclear function.
W T, Schrader, B W, O'Malley
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Chaperones in progesterone receptor complexes

Seminars in Cell & Developmental Biology, 2000
Studying the components, pathways, and dynamics of progesterone receptor (PR) assembly with chaperones has provided a highly valuable model system for understanding the coordinate actions of chaperones. Chaperones are primarily adapted to facilitate protein folding processes, and the actions of chaperones toward PR and other steroid receptors probably ...
openaire   +2 more sources

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