Results 261 to 270 of about 152,856 (310)

Progesterone-Progestin Receptors

1974
A correlation between binding to the progestin-specific uterine cytosol receptor and with well-defined facets of progesterone action was established. Structurally similar derivatives of norprogesterone and nortestosterone were compared. Binding was measured in vitro by determining their competitive effect on the progestin-tagged uterine cytosol ...
J P, Raynaud, D, Philibert, G, Azadian-Boulanger   +2 more
openaire   +2 more sources

Progesterone receptor and the mechanism of action of progesterone antagonists

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type II compounds (RU486, ZK112993, ZK98734) promote PR binding to DNA.
D P, Edwards, M, Altmann, A, DeMarzo, Y, Zhang, N L, Weigel, C A, Beck   +5 more
openaire   +2 more sources

Phosphorylation and Progesterone Receptor Function

The Journal of Steroid Biochemistry and Molecular Biology, 1994
Four phosphorylation sites have been identified in the chicken progesterone receptor. Two of these sites exhibit basal phosphorylation which is enhanced upon treatment with hormone and two of the sites are phosphorylated in response to hormone. Mutation of one of these hormone dependent sites, Ser530 to Ala530, causes a decrease in transcriptional ...
N. L. Weigel, W. Bai, Y. Zhang, C. A. Beck, D. P. Edwards, A. Poletti   +5 more
openaire   +3 more sources

The evolution of progesterone receptor ligands

Medicinal Research Reviews, 2006
AbstractProgesterone is one of the first nuclear receptor hormones to be described functionally and subsequently approached as a drug target. Because progesterone (1) affects both menstruation and gestation via the progesterone receptor (PR), research aimed at modulating its activity is usually surrounded by controversy.
Kevin P, Madauss, Eugene L, Stewart, Shawn P, Williams   +2 more
openaire   +2 more sources

Progesterone Receptors and Ovulation

2010
The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. The physiological effects of progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which are produced from a single gene and upon binding progesterone regulate the expression of specific gene networks in reproductive tissues.
openaire   +2 more sources

Progesterone ”Receptor“ in Rat Ovary*

Endocrinology, 1979
A soluble thermolabile protein with many characteristics of a progesterone receptor has been identified in ovaries of estrogen-stimulated, hypophysectomized, immature female rats. A potent synthetic progestin R5020 (17,21-dimethyl-19-nor-pregna-4, 9-diene-3, 20-dione) and a progestin-receptor complex stabilizer (glycerol) were employed.
J R, Schreiber, J W, Hsueh
openaire   +2 more sources

Progesterone Receptor Signaling Mechanisms

Journal of Molecular Biology, 2016
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer.
Sandra L, Grimm, Sean M, Hartig, Dean P, Edwards   +2 more
openaire   +2 more sources

Progesterone Receptors in Rat Thymus

Endocrinology, 1983
Tritiated promegestone ([3H]R5020) is bound with high affinity in cytosol prepared from the thymus gland of both male and female rats. To prevent tracer binding to glucocorticoid receptors, we have used excess RU26988 (11 beta, 17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one), a highly specific synthetic glucocorticoid.
P T, Pearce, B A, Khalid, J W, Funder
openaire   +2 more sources

Activation of Progesterone Receptor by ATP

European Journal of Biochemistry, 1981
Progesterone-receptor complex from freshly prepared hen oviduct cytosol acquired the ability to bind to isolated nuclei, DNA-cellulose and ATP-Sepharose when incubated with 5-10 mM ATP at 4 degrees C. The extent of this ATP-dependent activation was higher when compared with heat-activation achieved by warming the progesterone-receptor complex at 23 ...
V, Moudgil, V, Kruczak, T, Eessalu, C S, Paulose, M, Taylor, J, Hansen   +5 more
openaire   +2 more sources

Progesterone and the progesterone receptor.

The Journal of reproductive medicine, 2001
During the 1990s, extensive research has effectively mapped the progesterone receptor-mediated actions of progesterone and has more recently uncovered nonreceptor-mediated effects--the effect of progesterone on uterine sensitivity to oxytocin, for example, involves direct, nongenomic progesterone action on the uterine oxytocin receptor.
openaire   +1 more source