Results 141 to 150 of about 709,109 (292)

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements. [PDF]

CNS Neurosci Ther
Hu SS, Zhang CF, Lkhagvasuren B, Wang D.
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety. [PDF]

Int J Mol Sci
Grzybowski F, Kaczmarski P, Strzelecki D, Wysokiński A, Białasiewicz P, Gabryelska A.   +5 more
europepmc   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Tryptophan Supplementation Reduces Schizophrenia-Like Symptoms in Apomorphine Treated Rats: Role of D2, GABA, and Glutamate Receptor Expression. [PDF]

Int J Tryptophan Res
Nawaz S, Ali SB, Afroz R, Ikram H, Khan F, Haleem DJ.   +5 more
europepmc   +1 more source

Direct Conversion of Aryl Iodides Into Benzylamines by Aminomethylation: Reaction Scope, Mechanistic Studies, and Applications

European Journal of Organic Chemistry, EarlyView.
This study presents an efficient aminomethylation of aryl iodides with formamides for the synthesis of benzylamines using a reusable palladium catalyst at a loading of 65 mol ppm. The substrate scope is systematically evaluated, and mechanistic investigations provide insight into the reaction pathway and the origin of the observed catalytic efficiency.
Abhijit Sen, Atsuya Muranaka, Yu Hatakenaka, Aya Ohno, Yoichi M. A. Yamada   +4 more
wiley   +1 more source

Serotonergic System Dysregulation in Alzheimer's Disease. [PDF]

ACS Chem Neurosci
Al-Ghraiybah NF, Alkhalifa AE, Spivey D, Averill T, Engelkemier B, Haro Lopez P, Stuckey MG, Jenkins L, Kaddoumi A.   +8 more
europepmc   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

Phosphatase Inhibition Attenuates the Negative Inotropic Effect of Muscarinic Receptors in the Presence of Serotonin. [PDF]

Curr Issues Mol Biol
Schwarz R, Hofmann B, Gergs U, Kirchhefer U, Neumann J.   +4 more
europepmc   +1 more source