5-HT Receptors and Temperature Homeostasis [PDF]
Biomolecules, 2021 The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance.
Irina P. Voronova
doaj +5 more sources
The role of 5-HT receptors in depression [PDF]
Molecular Brain, 2017 Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide.
Christine N. Yohn +2 more
doaj +4 more sources
Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease. [PDF]
Int J Mol Sci, 2023 Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors may play a role in sepsis, ischaemia, and reperfusion.
Neumann J, Hofmann B, Dhein S, Gergs U.
europepmc +5 more sources
Comparative analysis of palmitoylation sites of serotonin (5‐HT) receptors in vertebrates [PDF]
Neuropsychopharmacology Reports, 2018 Background In the vertebrate central nervous system as well as in the periphery, serotonin, also known as 5‐hydroxytriptamine (5‐HT), function as a neurotransmitter, a hormone or a mitogen.
Toshie Kaizuka, Takashi Hayashi
doaj +2 more sources
Natural Negative Allosteric Modulators of 5-HT3 Receptors [PDF]
Molecules, 2018 Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT3; serotonin ...
Lina T. Al Kury +3 more
doaj +2 more sources
Serotonin signaling modulates growth and motility in juvenile Fasciola hepatica. [PDF]
PLoS Neglected Tropical DiseasesFasciola hepatica causes fasciolosis, a parasitic disease that poses significant animal and human health challenges. Control relies on flukicides, most of which are adulticides, with only triclabendazole effective against the pathogenic migratory ...
Emily Robb +10 more
doaj +2 more sources
Constitutively active 5-HT receptors: An explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not a enteric neurotransmitter ? [PDF]
Frontiers in Cellular Neuroscience, 2015 Antagonists of 5-Hydroxytryptamine (5-HT) receptors are well known to inhibit gastrointestinal (GI)-motility and transit in a variety of mammals, including humans.
Nick eSpencer
doaj +2 more sources
Serotonergic modulation of excitatory synapse development and plasticity [PDF]
Molecules and Cells: Excitatory synapse plasticity at postsynaptic dendritic spines is directly modulated through neurotransmitter signaling. Serotonin (5-HT) is a primary neuromodulator in the brain that activates 14 subtypes of G-protein-coupled receptors, each with ...
Victoria N. Chang +3 more
doaj +2 more sources
Can Serotonin 7 Receptors Be a Treatment Target for Noncentral Diseases?
Eurasian Journal of Medicine, 2023 The neurotransmitter serotonin (5-HT) is involved in several key processes in the central nervous system. But the great majority of serotonin is produced by intestinal enterochromafn cells of the gastrointestinal (GI) tract and circulating blood ...
Aslı Özbek Bilgin
doaj +1 more source
5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability
iScience, 2023 Summary: Many psychiatric diseases have been associated with serotonin (5-HT) neuron dysfunction. The firing of 5-HT neurons is known to be under 5-HT1A receptor-mediated autoinhibition, but functional consequences of coexpressed receptors are unknown ...
Amina Benhadda +8 more
doaj +1 more source