Results 1 to 10 of about 285,668 (244)
The serotonergic system dysfunction in diabetes mellitus
Frontiers in Cellular Neuroscience, 2022 Most peripheral serotonin (5-HT) is synthesized in enterochromaffin cells, and most circulating 5-HT is stored in platelets. As a monoamine, 5-HT has several functions in various non-neuronal and neuronal systems.
Yan Cai +3 more
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5-HT Receptors and Temperature Homeostasis
Biomolecules, 2021 The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance.
Irina P. Voronova
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Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety
Frontiers in Synaptic Neuroscience, 2023 Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or depression which negatively impacts the patient’s overall quality ...
Shun Hao +11 more
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Can Serotonin 7 Receptors Be a Treatment Target for Noncentral Diseases?
Eurasian Journal of Medicine, 2023 The neurotransmitter serotonin (5-HT) is involved in several key processes in the central nervous system. But the great majority of serotonin is produced by intestinal enterochromafn cells of the gastrointestinal (GI) tract and circulating blood ...
Aslı Özbek Bilgin
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Current Research in Neurobiology, 2023 Brain serotonin (5-hydroxytryptamine, 5-HT) is a key molecule for the mediation of depression-related brain states, but the neural mechanisms underlying 5-HT mediation need further investigation.
Yuki Higuchi, Hiroyuki Arakawa
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Animals, 2023 Serotonin (5-HT) is primarily distributed in the gastrointestinal and central nervous systems, where it plays a crucial role in regulating various physiological functions such as digestion, reproduction and establishing animal emotions.
Qiyi You +5 more
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Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases
Frontiers in Immunology, 2020 Serotonin, also known as 5-hydroxytryptamine (5-HT) is a signaling mediator that regulates emotion, behavior, and cognition. Previous studies have focused more on the roles of 5-HT in the central nervous system (CNS).
Minjie Wan +7 more
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Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer
Molecular Therapy: Nucleic Acids, 2022 Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression is sustained by recruitment of a strong tumor microenvironment (TME) mainly composed of cancer-associated fibroblasts (CAFs) able to endorse tumor ...
Iolanda Scognamiglio +15 more
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Insects, 2022 Serotonin (5-HT) plays a vital role in many physiological processes in insects, regulating physiological activities such as growth and movement through multiple 5-HT receptors (5-HTRs), which were potential targets for some new insecticides. However, the
Miaozhen Li +8 more
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Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
International Journal of Molecular Sciences, 2023 Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors may play a role in sepsis, ischaemia, and reperfusion.
Joachim Neumann +3 more
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