Results 31 to 40 of about 24,807,512 (318)
5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Nature, 2018 Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits.
J. Walsh +7 more
semanticscholar +1 more source
The role of 5-HT receptors in depression
Molecular Brain, 2017 Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide.
C. Yohn, Mark M. Gergues, B. Samuels
semanticscholar +1 more source
Molecules, 2022 Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed ...
Margherita Mastromarino +8 more
doaj +1 more source
Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
Journal of Neuroscience, 2017 The serotonin (5-HT) system and the amygdala are key regulators of emotional behavior. Several lines of evidence suggest that 5-HT transmission in the amygdala is implicated in the susceptibility and drug treatment of mood disorders.
Ayesha Sengupta +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2013 Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as ...
Naozumi eAraragi +5 more
doaj +1 more source
Effects of 5‐HT₃ receptor antagonists on cisplatin‐induced kidney injury
Clinical and Translational Science, 2021 Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin‐induced kidney injury has ...
Mitsuhiro Goda +13 more
doaj +1 more source
Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate
Neuron, 2014 Summary The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-hydroxytryptamine; 5-HT) expressing neurons. Serotonergic neurons in the DRN have been theorized to encode punishment by opposing the reward signaling of dopamine ...
Zhixiang Liu +14 more
semanticscholar +1 more source
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models. [PDF]
PLoS ONE, 2015 The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy ...
Karolina Pytka +15 more
doaj +1 more source
Shipin gongye ke-ji, 2023 Objective: To study the sleep-improving effect of Ziziphi spinosae Semen Poria cocos powder and soybean peptide powder on insomnia model mice induced by p-chlorophenylalanine (PCPA). Methods: One hundred eighty SPF male BALB/c mice were purchased. First,
Rong WEI +4 more
doaj +1 more source
Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production [PDF]
Clinical and Molecular HepatologyBackground/Aims Cholestatic liver disease (CLD) is a pathological condition characterized by impaired bile formation, secretion, and excretion.
Dianji Tu +21 more
doaj +1 more source