Results 11 to 20 of about 285,668 (244)

The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To examine the effect and potential mechanism of electroacupuncture (EA) pretreatment in spatial learning, memory, gut microbiota, and JNK signaling in D-galactose-induced AD-like rats.
Min Xiao, Xue-Song Wang, Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Li-Hong Kong   +5 more
doaj   +1 more source

Serotonin regulates osteoblast proliferation and function in vitro

Brazilian Journal of Medical and Biological Research, 2014
The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation ...
S.Q. Dai, L.P. Yu, X. Shi, H. Wu, P. Shao, G.Y. Yin, Y.Z. Wei   +6 more
doaj   +1 more source

Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A

Disease Models & Mechanisms, 2022
Serotonin (5-HT) is one of the key bioamines of nonalcoholic fatty liver disease (NAFLD). Its mechanism of action in autonomic neural signal pathways remains unexplained; hence, we evaluated the involvement of 5-HT and related signaling pathways via ...
Takashi Owaki, Kenya Kamimura, Masayoshi Ko, Itsuo Nagayama, Takuro Nagoya, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Takeki Sato, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Shuji Terai   +14 more
doaj   +1 more source

Effects of Serotonergic Agonists and Antagonists on the Competitive Behaviour of Rats [PDF]

Records of Pharmaceutical & Biomedical Sciences
SWhen  animals  are  housed  in  a  group,  they  form  social  hierarchy,  which  may have a great influence on the cognitive abilities and health of the individuals of this group. The rank order of this social hierarchy may have its consequences on the
Mirna ElAwady, Reem Hazem, Manal Abdelhady, Dina Khodeer   +3 more
doaj   +1 more source

Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat

Biomedicines, 2023
A recognized vasodilator, the infusion of 5-hydroxytryptamine (5-HT, serotonin) decreases blood pressure through the reduction of total peripheral resistance in the rat. It is not clear which vascular beds/tissues are responsible for this fall.
Benjamin Butler, Hannah Garver, Stephanie W. Watts, Gregory D. Fink   +3 more
doaj   +1 more source

Role of NOX/ROS in 5-HT-mediated proliferation of rat pulmonary artery smooth muscle cells

Di-san junyi daxue xuebao, 2020
Objective To observe whether serotonin (5-HT)-mediated proliferation of pulmonary artery smooth muscle cells (PASMCs) is related to the increase of intracellular reactive oxygen species (ROS), and identify the role of NADPH oxidase (NOX) in the ...
ZHANG Ying, CHEN Lin, CHEN Yang, YI Bin, CHEN Jie   +4 more
doaj   +1 more source

Constitutively active 5-HT receptors: An explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not a enteric neurotransmitter ?

Frontiers in Cellular Neuroscience, 2015
Antagonists of 5-Hydroxytryptamine (5-HT) receptors are well known to inhibit gastrointestinal (GI)-motility and transit in a variety of mammals, including humans.
Nick eSpencer
doaj   +1 more source

Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism

Pharmacology Research & Perspectives, 2023
Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura, Shuji Komatsu, Toshihiko Yamada, Hiromi Kitahara, Tatsuo Yamamoto   +4 more
doaj   +1 more source

Ritanserin as an adjunct to lithium and haloperidol for the treatment of medication-naive patients with acute mania: a double blind and placebo controlled trial

BMC Psychiatry, 2003
Background Bipolar disorder is a lifelong episodic condition characterized by mood swings between mania and depression. Several lines of evidence suggest that serotonin is likely to play a pivotal role in the pathophysiology of bipolar disorder ...
Mohammadi Mohammad, Mohajari Hassan, Akhondzadeh Shahin, Amini Homayoun   +3 more
doaj   +1 more source

Effects of 5‐HT₃ receptor antagonists on cisplatin‐induced kidney injury

Clinical and Translational Science, 2021
Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin‐induced kidney injury has ...
Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa‐Ishizawa, Keisuke Ishizawa   +13 more
doaj   +1 more source