Results 11 to 20 of about 24,807,512 (318)
5-HT1B receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra
Neuroscience, 2010 Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule.
Threlfell, S, Greenfield, S, Cragg, S
openaire +3 more sources
Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain [PDF]
, 2012 [eng] The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused on drug discovery of 5-HT7
Brenchat Barberà, Àlex
core +6 more sources
Drugs Affecting 5-HT Systems [PDF]
, 2013 Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core +4 more sources
Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer
Molecular Therapy: Nucleic Acids, 2022 Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. TNBC progression is sustained by recruitment of a strong tumor microenvironment (TME) mainly composed of cancer-associated fibroblasts (CAFs) able to endorse tumor ...
Iolanda Scognamiglio +15 more
doaj +1 more source
Insects, 2022 Serotonin (5-HT) plays a vital role in many physiological processes in insects, regulating physiological activities such as growth and movement through multiple 5-HT receptors (5-HTRs), which were potential targets for some new insecticides. However, the
Miaozhen Li +8 more
doaj +1 more source
The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]
, 2014 Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A. +2 more
core +5 more sources
Central 5-HT receptors and their function; present and future.
Neuropharmacology, 2020 Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT receptors have been discovered and there is little evidence that this situation will change in the near future.
T. Sharp, N. Barnes
semanticscholar +1 more source
The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To examine the effect and potential mechanism of electroacupuncture (EA) pretreatment in spatial learning, memory, gut microbiota, and JNK signaling in D-galactose-induced AD-like rats.
Min Xiao +5 more
doaj +1 more source
Serotonin regulates osteoblast proliferation and function in vitro
Brazilian Journal of Medical and Biological Research, 2014 The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation ...
S.Q. Dai +6 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Serotonin (5-HT) is one of the key bioamines of nonalcoholic fatty liver disease (NAFLD). Its mechanism of action in autonomic neural signal pathways remains unexplained; hence, we evaluated the involvement of 5-HT and related signaling pathways via ...
Takashi Owaki +14 more
doaj +1 more source