Effects of Serotonergic Agonists and Antagonists on the Competitive Behaviour of Rats [PDF]
Records of Pharmaceutical & Biomedical SciencesSWhen animals are housed in a group, they form social hierarchy, which may have a great influence on the cognitive abilities and health of the individuals of this group. The rank order of this social hierarchy may have its consequences on the
Mirna ElAwady +3 more
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Pharmacology Research & Perspectives, 2023 Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura +4 more
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Role of NOX/ROS in 5-HT-mediated proliferation of rat pulmonary artery smooth muscle cells
Di-san junyi daxue xuebao, 2020 Objective To observe whether serotonin (5-HT)-mediated proliferation of pulmonary artery smooth muscle cells (PASMCs) is related to the increase of intracellular reactive oxygen species (ROS), and identify the role of NADPH oxidase (NOX) in the ...
ZHANG Ying +4 more
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Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat
Biomedicines, 2023 A recognized vasodilator, the infusion of 5-hydroxytryptamine (5-HT, serotonin) decreases blood pressure through the reduction of total peripheral resistance in the rat. It is not clear which vascular beds/tissues are responsible for this fall.
Benjamin Butler +3 more
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5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to Its subsequent release [PDF]
, 2014 The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher +5 more
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Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites
Molecular Metabolism, 2018 Objectives 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract.
M. L. Lund +6 more
semanticscholar +1 more source
5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]
, 2009 A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...
Smith, M. A. +9 more
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Frontiers in Cellular Neuroscience, 2015 Antagonists of 5-Hydroxytryptamine (5-HT) receptors are well known to inhibit gastrointestinal (GI)-motility and transit in a variety of mammals, including humans.
Nick eSpencer
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Inhibition of native 5-HT3 receptor-evoked contractions in Guinea pig and mouse ileum by antimalarial drugs [PDF]
, 2014 Quinine, Chloroquine and mefloquine are commonly used to treat malaria; however with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis.
Walsh, Jacqueline M. +9 more
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BMC Psychiatry, 2003 Background Bipolar disorder is a lifelong episodic condition characterized by mood swings between mania and depression. Several lines of evidence suggest that serotonin is likely to play a pivotal role in the pathophysiology of bipolar disorder ...
Mohammadi Mohammad +3 more
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