Results 21 to 30 of about 285,668 (244)

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties

Molecules, 2022
Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed ...
Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo   +8 more
doaj   +1 more source

Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis

Frontiers in Pharmacology, 2013
Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as ...
Naozumi eAraragi, Boris eMlinar, Gilda eBaccini, Lise eGutknecht, Klaus-Peter eLesch, Renato eCorradetti   +5 more
doaj   +1 more source

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models. [PDF]

PLoS ONE, 2015
The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy ...
Karolina Pytka, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Grzegorz Kazek, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Marian Błachuta, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Anna Wesołowska   +15 more
doaj   +1 more source

Study on the Effect of Ziziphi spinosae Semen Poria cocos Powder and Soybean Peptide Powder on Improving Sleep in Insomnia Model Mice

Shipin gongye ke-ji, 2023
Objective: To study the sleep-improving effect of Ziziphi spinosae Semen Poria cocos powder and soybean peptide powder on insomnia model mice induced by p-chlorophenylalanine (PCPA). Methods: One hundred eighty SPF male BALB/c mice were purchased. First,
Rong WEI, Zhen WANG, Huaiping LI, Yu GUO, Jian ZHAO   +4 more
doaj   +1 more source

The temperament mediates the serotonergic activity and severity of ADHD in children: Literature review

Revista de Psicología y Ciencias del Comportamiento de la Unidad Académica de Ciencias Jurídicas y Sociales, 2021
There are numerous reports about the relationship between the dopaminergic system and temperament in attention deficit and hyperactivity disorder (ADHD) yet, these reports avoid the study of the serotonergic system.
Abraham Dávalos Almonací, Vania Aldrete-Cortez, Gabriel Manjarrez   +2 more
doaj   +1 more source

Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production [PDF]

Clinical and Molecular Hepatology
Background/Aims Cholestatic liver disease (CLD) is a pathological condition characterized by impaired bile formation, secretion, and excretion.
Dianji Tu, Cheng Lu, Junfeng Guo, Qiao Chen, Xin Li, Yingjie Wang, Lulu Cheng, Hongfei Jiang, Jincheng Jian, Yusong Ge, Zhanjie Hou, Xiaojie Feng, Yunxuan Feng, Jianchun Zhou, Yuanyuan Lei, Hua Diao, Lei Ran, Yuanyuan Zhou, Zhengguo Xu, Jiyin Zhou, Bo Tang, Shiming Yang   +21 more
doaj   +1 more source

Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release

Frontiers in Bioscience-Landmark, 2023
Background: The activation of subcutaneous mast cells (MCs) helps to trigger the analgesic effect induced by acupuncture (AP), a traditional oriental therapy, that has been gradually accepted worldwide.
Bing-Rong Li, Yu-Jia Li, Jing-Wen Xu, Meng Huang, Li-Na Wang, Di Zhang, Xue-Yong Shen, Guang-Hong Ding   +7 more
doaj   +1 more source

Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan, Lindsay A. Renfro, Yue Wu, Katia M. Crisler, Erin Marcotte, Tanya Trippett, Terzah Horton, Bradford S. Hoppe, Frank G. Keller, Chris Forlenza, Cindy Schwartz, Kara M. Kelly, Peter D. Cole, Sharon M. Castellino, Justine M. Kahn   +14 more
wiley   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

SAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway

Journal of Inflammation Research, 2022
Jian Shen,1 Bimeng Zhang,2 Jianjie Chen,3 Jiazheng Cheng,1 Jiali Wang,1 Xianhui Zheng,1 Yu Lan,1 Xiaowen Zhang1 1Department of Pediatrics, Shuguang Hospital Affiliated to Shanghai Traditional Chinese Medical University, Shanghai, 201203, People’s ...
Shen J, Zhang B, Chen J, Cheng J, Wang J, Zheng X, Lan Y, Zhang X   +7 more
doaj