Results 51 to 60 of about 24,807,512 (318)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

MAOB rs3027452 Modifies Mood Improvement After Tryptophan Supplementation

International Journal of General Medicine, 2021
Irene Gonzalez,1 Rocio Polvillo,1,2 Maximiliano Ruiz-Galdon,1 Armando Reyes-Engel,1 Jose Luis Royo1 1Department of Surgery, Biochemistry and Immunology School of Medicine, University of Malaga, Malaga, Spain; 2Centro Andaluz de Biología del ...
Gonzalez I, Polvillo R, Ruiz-Galdon M, Reyes-Engel A, Royo JL   +4 more
doaj  

5-HT Radioligands for Human Brain Imaging With PET and SPECT

Medicinal research reviews (Print), 2011
The serotonergic system plays a key modulatory role in the brain and is the target for many drug treatments for brain disorders either through reuptake blockade or via interactions at the 14 subtypes of 5‐HT receptors.
L. Paterson, B. R. Kornum, D. Nutt, V. W. Pike, G. M. Knudsen   +4 more
semanticscholar   +1 more source

Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation [PDF]

, 2007
5-Hydroxytryptamine (5-HT) is proarrhythmic in atrial cells from patients in sinus rhythm (SR) via activation of 5-HT₄ receptors, but its effects in atrial cells from patients with atrial fibrillation (AF) are unknown.
Kane, K.A., Kane, Kathleen A., Rankin, A.C., Workman, Antony J., Pau, Davide, Workman, A.J., Rankin, Andrew C., Pau, D.   +7 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons

Frontiers in Synaptic Neuroscience, 2022
Acute regulation of CO2 and pH homeostasis requires sensory feedback from peripheral (carotid body) and central (central) CO2/pH sensitive cells – so called respiratory chemoreceptors.
Gary C. Mouradian, Gary C. Mouradian, Pengyuan Liu, Pablo Nakagawa, Pablo Nakagawa, Erin Duffy, Javier Gomez Vargas, Javier Gomez Vargas, Kirthikaa Balapattabi, Kirthikaa Balapattabi, Justin L. Grobe, Justin L. Grobe, Justin L. Grobe, Justin L. Grobe, Justin L. Grobe, Curt D. Sigmund, Curt D. Sigmund, Curt D. Sigmund, Matthew R. Hodges, Matthew R. Hodges   +19 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Role of 5-HT_1A and 5-HT₇ Receptors in Memory Regulation and the Importance of Their Coexpression: A Systematic Review

Biomolecules
The 5-HT1A and 5-HT7 receptors play a key role in regulating cognitive processes and have been widely linked to the pathophysiology of depression, anxiety, and schizophrenia—disorders often associated with memory impairment.
Alfredo Briones-Aranda, Daniela Flores-Durán, Rodrigo Romero-Nava, Josselin Carolina Corzo-Gómez, Refugio Cruz-Trujillo, Floribert Toalá-Sepúlveda, Blanca E. Del-Río-Navarro, Fengyang Huang   +7 more
doaj   +1 more source

A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer’s disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil

Alzheimer’s Research & Therapy, 2018
Background Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in humans at a dose ...
Terence Fullerton, Brendon Binneman, William David, Marielle Delnomdedieu, James Kupiec, Peter Lockwood, Jessica Mancuso, Jeffrey Miceli, Joanne Bell   +8 more
doaj   +1 more source

A Genetically Defined Morphologically and Functionally Unique Subset of 5-HT Neurons in the Mouse Raphe Nuclei

Journal of Neuroscience, 2011
Heterogeneity of central serotonin (5-HT) raphe neurons is suggested by numerous lines of evidence, but its genetic basis remains elusive. The transcription factor Pet1 is required for the acquisition of serotonergic identity in a majority of neurons in ...
V. Kiyasova, S. Fernandez, J. Lainé, Léa Stankovski, A. Muzerelle, S. Doly, P. Gaspar   +6 more
semanticscholar   +1 more source