Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]
PLoS ONE, 2009 The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes +6 more
doaj +3 more sources
Molecular biology of 5-HT receptors.
Behavioural Brain Research, 2008 Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion
Hannon, Jason, Hoyer, Daniel
core +3 more sources
Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease. [PDF]
Int J Mol Sci, 2023 Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-receptors may play a role in sepsis, ischaemia, and reperfusion.
Neumann J, Hofmann B, Dhein S, Gergs U.
europepmc +5 more sources
Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain [PDF]
, 2012 [eng] The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused on drug discovery of 5-HT7
Brenchat Barberà, Àlex
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Drugs Affecting 5-HT Systems [PDF]
, 2013 Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core +4 more sources
The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]
, 2014 Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A. +2 more
core +5 more sources
Potential Anti-Amnesic Activity of a Novel Multimodal Derivative of Salicylamide, JJGW08, in Mice
Pharmaceuticals, 2023 Memory impairments constitute a significant problem worldwide, and the COVID-19 pandemic dramatically increased the prevalence of cognitive deficits. Patients with cognitive deficits, specifically memory disturbances, have underlying comorbid conditions ...
Elżbieta Żmudzka +7 more
doaj +1 more source
Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics. [PDF]
PLoS ONE, 2012 BACKGROUND: It is important to develop novel antipsychotics that can effectively treat schizophrenia with minor side-effects. The aim of our work is to develop novel antipsychotics that act on dopamine D(2) and D(3), serotonin 5-HT(1A) and 5-HT(2A ...
Yin Chen +5 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: The activation of subcutaneous mast cells (MCs) helps to trigger the analgesic effect induced by acupuncture (AP), a traditional oriental therapy, that has been gradually accepted worldwide.
Bing-Rong Li +7 more
doaj +1 more source
5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to Its subsequent release [PDF]
, 2014 The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher +5 more
core +1 more source