Insects, 2022 Serotonin (5-HT) plays a vital role in many physiological processes in insects, regulating physiological activities such as growth and movement through multiple 5-HT receptors (5-HTRs), which were potential targets for some new insecticides. However, the
Miaozhen Li +8 more
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Neural Basis for the Ability of Atypical Antipsychotic Drugs to Improve Cognition in Schizophrenia [PDF]
, 2013 Cognitive impairments are considered to largely affect functional outcome in patients with schizophrenia, other psychotic illnesses, or mood disorders. Specifically, there is much attention to the role of psychotropic compounds acting on serotonin (5-HT)
Takashi Uehara +2 more
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Frontiers in Cellular Neuroscience, 2022 Depression and anxiety are common, debilitating psychiatric conditions affecting millions of people throughout the world. Current treatments revolve around selective serotonin reuptake inhibitors (SSRIs), yet these drugs are only moderately effective at ...
Nikita Deo, Gregory Redpath
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Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]
, 2001 Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Boer, Sietse F. de, +5 more
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Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]
, 2010 Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica +8 more
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Serotonergic modulation of spatial working memory: predictions from a computational network model
Frontiers in Integrative Neuroscience, 2013 Serotonin (5-HT) receptors of types 1A and 2A are massively expressed in prefrontal cortex (PFC) neurons, an area associated with cognitive function. Hence, 5-HT could be effective in modulating prefrontal-dependent cognitive functions, such as spatial ...
Maria eCano-Colino +3 more
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Pharmacological profile of novel psychoactive benzofurans [PDF]
, 2015 Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Hoener, Marius C. +3 more
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A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension
Biomedicines, 2023 Serotonin (5-HT) is a bioamine that has been implicated in the pathogenesis of pulmonary hypertension (PH). The lung serves as an important site of 5-HT synthesis, uptake, and metabolism with signaling primarily regulated by tryptophan hydroxylase (TPH),
Jamie L. Archambault, Cassidy A. Delaney
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Quinine blocks 5-HT and 5-HT3 receptor mediated peristalsis in both guinea pig and mouse ileum tissue [PDF]
, 2011 Introduction. Quinine is commonly used to treat malaria; however one of the principal side effects is gastrointestinal disturbances (White, 1992). 5-HT3 receptors modulate gut peristalsis (Chetty et al., 2006), and, as quinine has been shown to act as a ...
Barrett, Iain D. +4 more
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Effect of serotonin axon injury on the somatostatinergic system in rat frontoparietal cortex [PDF]
, 1993 In order to investigate the possibility that, in the rat, some cerebral cortex\ud somatostatin (SS) receptors may be localized presynaptically on the terminals of\ud serotonergic neurons, serotonin [5-hydroxytryptamine, (5-HT)] neurons in the\ud central ...
Arilla Ferreiro, Eduardo +2 more
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