Results 21 to 30 of about 12,268,158 (295)
Influence of Serotonin 5-HT4 Receptors on Responses to Cardiac Stressors in Transgenic Mouse Models
Biomedicines, 2021 The current study aimed to deepen our knowledge on the role of cardiac 5-HT4 receptors under pathophysiological conditions. To this end, we used transgenic (TG) mice that overexpressed human 5-HT4a receptors solely in cardiac myocytes (5-HT4-TG mice) and
Ulrich Gergs +8 more
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Serotonin regulates osteoblast proliferation and function in vitro
Brazilian Journal of Medical and Biological Research, 2014 The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation ...
S.Q. Dai +6 more
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Journal of Biological Chemistry, 2012 5-Hydroxytryptamine type 3 (5-HT(3)) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT(3) receptor subunits (A-E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit sequence contribute to the agonist-binding site, and
openaire +2 more sources
Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice
The Journal of Reproduction and Development, 2019 In this study, we examined the effects of 5-hydroxytryptamine (5-HT) on the motility and hyperactivation of mouse spermatozoa. In addition, we examined whether 5-HT increases the success of in vitro fertilization (IVF) in mice.
Yukiko SUGIYAMA +2 more
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The Journal of Headache and Pain, 2022 Background 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo ...
Jacob C. A. Edvinsson +7 more
doaj +1 more source
Pharmaceuticals, 2023 Mental illnesses are a global health challenge, and effective medicines are needed to treat these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders, such as schizophrenia, but unfortunately, they can cause significant and ...
Ronald Mlambo +4 more
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Inhibition of native 5-HT3 receptor-evoked contractions in Guinea pig and mouse ileum by antimalarial drugs [PDF]
, 2014 Quinine, Chloroquine and mefloquine are commonly used to treat malaria; however with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis.
Walsh, Jacqueline M. +9 more
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Involvement of Serotonergic System in Oxaliplatin-Induced Neuropathic Pain
Biomedicines, 2021 Oxaliplatin is a chemotherapeutic agent widely used against colorectal and breast cancers; however, it can also induce peripheral neuropathy that can rapidly occur even after a single infusion in up to 80–90% of treated patients.
Ji Hwan Lee, Woojin Kim
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5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]
, 2009 A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...
Smith, M. A. +9 more
core +1 more source
The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy
Molecules, 2022 5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as a hormone in platelets.
Tomasz Guzel, Dagmara Mirowska-Guzel
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