Results 21 to 30 of about 87,483 (259)
Journal of Biological Chemistry, 2012 5-Hydroxytryptamine type 3 (5-HT(3)) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT(3) receptor subunits (A-E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit sequence contribute to the agonist-binding site, and
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Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice
The Journal of Reproduction and Development, 2019 In this study, we examined the effects of 5-hydroxytryptamine (5-HT) on the motility and hyperactivation of mouse spermatozoa. In addition, we examined whether 5-HT increases the success of in vitro fertilization (IVF) in mice.
Yukiko SUGIYAMA +2 more
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The Journal of Headache and Pain, 2022 Background 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo ...
Jacob C. A. Edvinsson +7 more
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Pharmaceuticals, 2023 Mental illnesses are a global health challenge, and effective medicines are needed to treat these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders, such as schizophrenia, but unfortunately, they can cause significant and ...
Ronald Mlambo +4 more
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Involvement of Serotonergic System in Oxaliplatin-Induced Neuropathic Pain
Biomedicines, 2021 Oxaliplatin is a chemotherapeutic agent widely used against colorectal and breast cancers; however, it can also induce peripheral neuropathy that can rapidly occur even after a single infusion in up to 80–90% of treated patients.
Ji Hwan Lee, Woojin Kim
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The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy
Molecules, 2022 5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as a hormone in platelets.
Tomasz Guzel, Dagmara Mirowska-Guzel
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5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. [PDF]
PLoS ONE, 2009 Beside its well described role in the central and peripheral nervous system 5-hydroxytryptamine (5-HT), commonly known as serotonin, is also a potent immuno-modulator.
Tobias Müller +11 more
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Study of nerve fibers nature reinforcing duodenal contractions by electrical stimulation of sympathetic nerve [PDF]
Саратовский научно-медицинский журнал, 2011 The subject of the article is to investigate the mechanism of increased reactions by electrical stimulation of the sympathetic nerve. Materials and methods: Experiments on dogs have shown that stimulant reactions during blockade of a-adrenergic by ...
Sveshnikov D.S. +6 more
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Serotonin modulation of cortical neurons and networks
Frontiers in Integrative Neuroscience, 2013 The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR, respectively) are critically involved in cortical function.
Pau eCelada +2 more
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Serotonin augments gut pacemaker activity via 5-HT3 receptors. [PDF]
PLoS ONE, 2011 Serotonin (5-hydroxytryptamine: 5-HT) affects numerous functions in the gut, such as secretion, muscle contraction, and enteric nervous activity, and therefore to clarify details of 5-HT's actions leads to good therapeutic strategies for gut functional ...
Hong-Nian Liu +8 more
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