Results 11 to 20 of about 110,518 (147)

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2001
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
core  

Allosteric Modulators of Steroid Hormone Receptors : Structural Dynamics and Gene Regulation [PDF]

, 2012
Peer reviewedPublisher ...
Acevedo, Almlöf, Almlöf, Almlöf, Andersen, Babu, Bain, Ball, Barkhem, Baskakov, Beck, Benecke, Berry, Betney, Bevan, Bhasin, Billon-Galés, Bledsoe, Blind, Bolton, Boonyaratanakornkit, Briet, Brodie, Brzozowski, Bulynko, Börjesson, Callewaert, Carlstedt-Duke, Carlstedt-Duke, Carroll, Carroll, Centenera, Chamberlain, Chandra, Chang, Chen, Chen, Chen, Claessens, Conneely, Connell, Cutress, Cutress, Dahlman-Wright, Dahlman-Wright, Dahlman-Wright, Daniel, Darimont, Davies, Demarest, Doesburg, Dong, Dubbink, Duma, Dunker, Dunker, Dunker, Dyson, Dziedzic-Letka, Egea, Eick, Eisenhaber, Escriva, Estébanez-Perpiñá, Evans, Faus, Fawell, Ferreira, Fischer, Freeman, Fu, Fu, Fu, Funder, Fuse, Garza, Garza, Gaughan, Gellersen, Georgiakaki, Glass, Govindan, Green, Green, Green, Greene, Groeneweg, Gronemeyer, He, He, He, He, Heery, Hermann, Hill, Hilser, Hollenberg, Hollenberg, Holthauzen, Huang, Hur, Härd, Iain J. McEwan, Iakoucheva, Iakoucheva, Iñiguez-Lluhí, Jeltsch, Jenster, Joerger, Jones, Kaul, Khan, Khan, Kininis, Kjaergaard, Ko, Konduri, Kornberg, Krasowski, Kraus, Kulkarni, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Kumar, Langley, Langley, Lanz, Lavery, Lavery, Lavery, Lefstin, Linding, Liu, Loven, Lubahn, Malik, Mao, Mao, Massie, McDonnell, McDonnell, McEwan, McEwan, McEwan, McEwan, McEwan, McEwen, McInerney, McKenna, McNally, Meijsing, Metzger, Midic, Miller, Mérot, Métivier, Nagaich, Nagy, Nettles, Nilsson, Nocula-£ugowska, Oakley, Oldfield, Onate, Paige, Picard, Pike, Pippal, Powell, Pratt, Prilusky, Putcha, Raj Kumar, Rajagopalan, Rayasam, Reid, Reid, Ricketson, Rochel, Roeder, Roemer, Rogatsky, Rogatsky, Rosenfeld, Savory, Schoenmakers, Schwabe, Schwabe, Shaffer, Shatkina, Shen, Shoemaker, Simental, Smith, Smith, So, So, Spillman, Stanisiæ, Stenoien, Street, Sugase, Surjit, Takimoto, Tanner, Tetel, Timasheff, Tompa, Tora, Tremblay, Tzukerman, Umetani, Uversky, Uversky, Vacic, van Royen, Verkhivker, Vicent, Wang, Wang, Wang, Wang, Wardell, Wardell, Wardell, Weigel, Weinberger, Wijayaratne, Wood, Wood, Wrange, Wright, Wärnmark, Xu, Yang, Yang, Yang, Yoon, Zennaro, Zhang, Zhao, Zilliacus, Zor   +251 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2017
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core  

Developmental and functional effects of steroid hormones on the neuroendocrine axis and spinal cord [PDF]

, 2016
This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual ...
Gonzalez Deniselle, Maria Claudia, Lara, H. E., Recabarren, S. E., Roselli, C. E., Zubeldia Brenner, Lautaro   +4 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source