Results 211 to 220 of about 42,405 (307)

Differential Regulation of Granule Release in Platelets and Immune Cells. [PDF]

TH Open
Xia Q, Hu J, Sun H, Zhu Z, Jiang W.
europepmc   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

The role of protease-activated receptors (PARs) in the functioning of platelets and platelet-derived microparticles (PMPs). [PDF]

Front Mol Biosci
Jakobsche-Policht U, Bronowicka-Szydełko A, Adamiec R, Bednarska-Chabowska D, Mierzchała-Pasierb M, Lewandowski Ł, Gostomska-Pampuch K, Adamiec-Mroczek J, Rabczyński M, Kuźnik E, Lubieniecki P, Dróżdż O, Martynowicz H, Kwiecień A, Strzelecka M, Rudkiewicz D, Piersiak M, Ziomek M, Kondracki M, Galińska Z, Madziarska K.   +20 more
europepmc   +1 more source

Investigator‐Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Investigator‐led research and quality improvement initiatives have led to important improvements in the diagnostic assessment of platelet function disorders (PFD). Methods Personal reflections were used to summarize our contributions to knowledge on PFD diagnostic assessment, pathogenesis, and bleeding risks.
Catherine P. M. Hayward
wiley   +1 more source

Is Fibrin a Suitable Matrix for Small-Diameter Bioartificial Vascular Grafts? An In Vitro Short-Term Hemocompatibility Study. [PDF]

J Funct Biomater
Glomb C, Stadler P, Klingenberg M, Pflaum M, Ruhparwar A, Wilhelmi M, Helms F.   +6 more
europepmc   +1 more source

Rapid Fibrinogen Assessment With the qLabs FIB Point‐of‐Care System: Results From a Multicenter Clinical Validation Study

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Acquired hypofibrinogenemia is frequently associated with major bleeding and requires prompt correction. Rapid and accurate quantification of fibrinogen is essential to guide hemostatic therapy and improve patient outcomes. The qLabs FIB system provides fibrinogen results within minutes at the bedside, supporting timely diagnostic ...
Sandra Sanfilippo, Leslie Buisson, Blanche Delabie, Sophie Le Bellego, Marie‐Eglantine Dujaric, Thibault Donnet   +5 more
wiley   +1 more source

Continuum and discrete modeling of binding-site distribution-mediated reactions on lipid surfaces. [PDF]

Biophys J
Cao H, Sen Gupta A, Leiderman K.
europepmc   +1 more source

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source

Targeting PAR1 biased signaling with parmodulin reduces thromboinflammation and acute lung injury in sickle cell disease. [PDF]

Blood Adv
Ramadas N, Lowder K, Dutton J, Kazen RC, Sellers R, DeRousse JT, Dockendorff C, Sparkenbaugh EM.   +7 more
europepmc   +1 more source

Forgotten Steps in the Coagulation Cascade

Haemophilia, EarlyView.
Quentin Van Thillo, Cedric Hermans
wiley   +1 more source