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Redox Control in Platelet Activity and Therapy. [PDF]
Antioxidants (Basel)Dionisio LM, Zheng Y, Cancelas JA.
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The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells. [PDF]
Front OncolBien-Möller S +11 more
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Phenotyping of human platelets in response to platelet agonists and inhibitors using multiparameter flow cytometry and unbiased high-dimensional analysis. [PDF]
Res Pract Thromb HaemostYates DM +5 more
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[Thrombin receptor in thrombosis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1997 openaire +1 more source
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Clinical and Experimental Pharmacology and Physiology, 1994
SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
P M, Dennington, M C, Berndt
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SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
P M, Dennington, M C, Berndt
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Thrombin receptor-activating peptide sensitizes the human endothelial thrombin receptor
American Journal of Physiology-Cell Physiology, 1995Receptor-operated effects of alpha-thrombin and of the thrombin receptor-activating peptide TRAP14 on cytoplasmic Ca2+ concentration ([Ca2+]i) were examined in fura 2-loaded endothelial cells. Experiments with hirudin showed that alpha-thrombin-induced Ca2+ influx requires the continuous presence of active alpha-thrombin.
H J, Kruse +3 more
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Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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Seminars in Thrombosis and Hemostasis, 1996
Thrombin's proteolytically activated "tethered-ligand" receptor is widely expressed and mediates many of thrombin's actions on cells. Its central role in thrombin-stimulated human platelet activation and vascular smooth muscle proliferation as well as location in atherosclerotic plaques suggests receptor involvement in arterial thrombosis and ...
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Thrombin's proteolytically activated "tethered-ligand" receptor is widely expressed and mediates many of thrombin's actions on cells. Its central role in thrombin-stimulated human platelet activation and vascular smooth muscle proliferation as well as location in atherosclerotic plaques suggests receptor involvement in arterial thrombosis and ...
openaire +2 more sources