Results 251 to 260 of about 1,086,464 (298)

Thyroid hormone receptors and reproduction

Journal of Reproductive Immunology, 2011
Thyroid disorders have a great impact on fertility in both sexes. Hyperthyroidism and hypothyroidism cause changes in sex hormone-binding globulin (SHBG), prolactin, gonadotropin-releasing hormone, and sex steroid serum levels. In females, thyroid hormones may also have a direct effect on oocytes, because it is known that specific binding sites for ...
Ralf, Dittrich, Matthias W, Beckmann, Patricia G, Oppelt, Inge, Hoffmann, Laura, Lotz, Torsten, Kuwert, Andreas, Mueller   +6 more
openaire   +2 more sources

Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology

Fertility and Sterility, 2011
To study the expression, distribution, and function of thyroid-stimulating hormone receptor (TSHR) and thyroid hormone receptors (TR) α1, α2, and β1 in human endometrium.Experimental clinical study.University hospital.31 fertile women.Endometrial biopsy samples obtained throughout the menstrual cycle.Real-time reverse transcriptase polymerase chain ...
Lusine Aghajanova, Britt-Marie Landgren   +1 more
exaly   +3 more sources

A structural role for hormone in the thyroid hormone receptor

Nature, 1995
The crystal structure of the rat alpha 1 thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphipathic helix, with its hydrophobic face constituting part of the ...
R L, Wagner, J W, Apriletti, M E, McGrath, B L, West, J D, Baxter, R J, Fletterick   +5 more
openaire   +2 more sources

Thyroid Hormone Receptors and Responses

1979
Publisher Summary This chapter discusses the responses of thyroid hormone receptors. The thyroid hormone receptor is unique in that it is an intrinsic chromosomal nonhistone protein known to be involved in the regulation of the expression of specific genes. These receptors are bound to chromatin in the absence or the presence of thyroid hormone. They
J D, Baxter, N L, Eberhardt, J W, Apriletti, L K, Johnson, R D, Ivarie, B S, Schachter, J A, Morris, P H, Seeburg, H M, Goodman, K R, Latham, J R, Polansky, J A, Martial   +11 more
openaire   +2 more sources

Thyroid Hormone Receptors

2010
Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM, Hong Liu, Douglas Forrest   +2 more
openaire   +1 more source

Thyroid Hormone Receptors

1995
Thyroid hormones notably Triiodothyronine (T3) and thyroxine (T4) play important roles in many biological processes in all vertebrates (De Groot et al, 1984). They affect growth, development and differentiation, metabolism and homeostasis. A particularly striking observation was made by Gudernatsch in the early part of this century that thyroid ...
F. Javier Piedrafita, Magnus Pfahl
openaire   +1 more source

Thyroid Hormone Receptors

Comprehensive Physiology, 1998
Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
openaire   +1 more source

Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors

Steroids, 2008
Confocal microscopy and cell fractionation studies have revealed the residence of nuclear thyroid hormone receptors (TR) in cytoplasm. Treatment of cells with the hormone (L-thyroxine or 3,5,3'-triiodo-L-thyronine, T(3)) results in shuttling of TR into the nuclear compartment. Confocal microscopy has also disclosed that TR in the nuclear compartment is
Paul J, Davis, Faith B, Davis, Hung-Yun, Lin   +2 more
openaire   +2 more sources

Resistance to Thyroid Hormone in a Patient Without Thyroid Hormone Receptor Mutations

Thyroid, 2002
Resistance to thyroid hormone (RTH) is a clinical syndrome characterized by elevated serum thyroid hormone (TH) levels, unsuppressed thyrotropin (TSH) levels, and tissue hyposensitivity to TH. In almost all cases, the genetic basis of RTH lies in mutation of one of the two TH receptor beta (TRbeta) alleles. Recently, patients from several families with
S, Parikh, S, Ando, A, Schneider, M C, Skarulis, N J, Sarlis, P M, Yen   +5 more
openaire   +2 more sources

Nuclear thyroid hormone receptors: ontogeny and thyroid hormone effects in sheep

American Journal of Physiology-Endocrinology and Metabolism, 1989
To investigate the mechanism(s) responsible for the paucity of fetal thyroid hormone effects, thyroid hormone nuclear receptor (T3NR) binding characteristics were quantified in liver and brain of fetal and neonatal sheep. Maximal binding capacities [MBC; mean +/- SE fmol 3,5,3'-triiodothyronine (T3)/mg DNA] in liver increased from values of 68 +/- 14 ...
D, Polk, D, Cheromcha, A, Reviczky, D A, Fisher   +3 more
openaire   +2 more sources